{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:09:39Z","timestamp":1792458579133,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study evaluated the remineralization potential of calcium sodium phosphosilicate and functionalized tri\u2010calcium phosphate (f\u2010TCP) dentifrices in deeper incipient carious lesions (ICLs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Artificial ICLs were created by placing premolars into demineralizing solutions. Teeth were randomly assigned into four groups: calcium sodium phosphosilicate (Group 1), f\u2010TCP (Group 2), 1450\u2009ppm fluoride (Group 3), and distilled water (Group 4), which were subjected to 10\u2010day\u00a0pH cycling. Mineral density (MD) was assessed using microcomputed tomography (Micro\u2010CT), while hardness (H) and elastic modulus (EM) were assessed using nanomechanical testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MD % gain was higher in Groups 1\u20133 than in Group 4. In addition, Groups 1 and 2 exhibited significantly higher MD % gain than Group 3. Also, Groups 1\u20133 showed significantly higher EM and H values than Group 4 in the outer enamel area; yet, Groups 1 and 2 displayed significantly higher EM and H values than Groups 3 and 4 in the inner enamel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The MD, EM, and H of ICLs significantly increased with the addition of calcium sodium phosphosilicate or f\u2010TCP to fluoridated dentifrices compared to standard fluoride dentifrices. The added active ingredients remineralized the deeper parts of the ICLs, while remineralization at the lesion surface was similar between tested dentifrices.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.876","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T11:14:27Z","timestamp":1710933267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Remineralization potential of dentifrices with calcium sodium phosphosilicate and functionalized tri\u2010calcium phosphate in the deeper incipient carious lesions: An in vitro study"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6971-738X","authenticated-orcid":false,"given":"Shafiq","family":"Aziz","sequence":"first","affiliation":[{"name":"Sir John Walsh Research Institute, Faculty of Dentistry University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8949-4008","authenticated-orcid":false,"given":"Carolina","family":"Loch","sequence":"additional","affiliation":[{"name":"Sir John Walsh Research Institute, Faculty of Dentistry University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5411-3065","authenticated-orcid":false,"given":"Kai Chun","family":"Li","sequence":"additional","affiliation":[{"name":"Sir John Walsh Research Institute, Faculty of Dentistry University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6278-9762","authenticated-orcid":false,"given":"Robert","family":"Anthonappa","sequence":"additional","affiliation":[{"name":"Paediatric Dentistry, UWA Dental School The University of Western Australia Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8234-3418","authenticated-orcid":false,"given":"Alison","family":"Meldrum","sequence":"additional","affiliation":[{"name":"Sir John Walsh Research Institute, Faculty of Dentistry University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9156-3727","authenticated-orcid":false,"given":"Manikandan","family":"Ekambaram","sequence":"additional","affiliation":[{"name":"Sir John Walsh Research Institute, Faculty of Dentistry University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.7126\/cumudj.432692"},{"issue":"4","key":"e_1_2_10_3_1","first-page":"186","article-title":"In situ remineralization of early caries by a new high\u2010fluoride dentifrice","volume":"60","author":"Amaechi B. 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