{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:34:42Z","timestamp":1791855282642,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Recent studies highlighted the role of miR expressed in saliva as reliable diagnostic and prognostic tools in the long\u2010term monitoring of cancer processes such as oral squamous carcinoma (OSCC). Based on a few previous studies, it seems the miR\u20103928 can be considered a master regulator in carcinogenesis, and it can be therapeutically exploited. This is the first study that compared oral\u00a0potentially malignant disorder (OLP) and malignant (OSCC) lesions for miR\u20103928 expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In this cross\u2010sectional study, saliva samples from 30 healthy control individuals, 30 patients with erosive\/atrophic oral lichen planus, and 31 patients\u00a0with\u00a0OSCC\u00a0were collected. The evaluation of miR\u20103928 expression by q\u2010PCR and its correlation with clinicopathological indices were analyzed by Shapiro\u2212Wilk, Kruskal\u2212Wallis, Pearson's\u00a0\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      , and Mann\u2212Whitney tests. The\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value less than .05 indicated statistically significant results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Based on nonparametric Kruskal\u2212Wallis test results, there was a statistically significant difference between the ages of three study groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). This test demonstrated a statistically significant difference between the average of miR\u20103928 expression in three study groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). The result of the\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0test showed a statistically significant difference in miR\u20103928 expression between patients with\u00a0OLP\u00a0(\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.01)\u00a0and also\u00a0patients with\u00a0OSCC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001)\u00a0in comparison to the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The salivary miR\u20103928 can play a tumor suppressive role in the pathobiology of OSCC, and it is significantly downregulated in patients. According to the potential tumor suppressive role of miR\u20103928 in the OSCC process, we can consider this microRNA as a biomarker for future early diagnosis, screening, and potential target therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.877","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T02:59:31Z","timestamp":1710385171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Downregulation of salivary miR\u20103928 as a potential biomarker in patients with\u00a0oral squamous cell carcinoma and oral lichen planus"],"prefix":"10.1002","volume":"10","author":[{"given":"Alieh","family":"Farshbaf","sequence":"first","affiliation":[{"name":"Dental Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Mohajertehran","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Diseases Research Center Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of Oral and Maxillofacial Pathology, School of Dentistry Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Hamid","family":"Aghaee\u2010Bakhtiari","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Bioinformatics Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Ayatollahi","sequence":"additional","affiliation":[{"name":"Hematology Department, Faculty of Medicine Mashhad University of Medical Science  Mashhad Iran"},{"name":"Pathology Department, Cancer Molecular Pathology Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katayoun","family":"Douzandeh","sequence":"additional","affiliation":[{"name":"Student Research Committee Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atessa","family":"Pakfetrat","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Diseases Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1262-4668","authenticated-orcid":false,"given":"Nooshin","family":"Mohtasham","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Diseases Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051723"},{"key":"e_1_2_10_3_1","volume-title":"TNM classification of malignant tumours","author":"Brierley J. 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