{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:26:06Z","timestamp":1787505966573,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T00:00:00Z","timestamp":1716681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["970776"],"award-info":[{"award-number":["970776"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study evaluates the efficacy of a novel mucoadhesive patch containing\n                      <jats:italic>Nigella sativa<\/jats:italic>\n                      10% extract compared to triamcinolone 0.1% in alleviating symptoms and reducing lesion severity in patients with erosive\u2010atrophic oral lichen planus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Materials<\/jats:title>\n                    <jats:p>\n                      A pilot study comprising two groups, each with 10 patients, was conducted. The intervention group received mucoadhesive patches containing\n                      <jats:italic>N. sativa<\/jats:italic>\n                      10% extract, while the control group received triamcinolone acetonide 0.1% patches. Pain and burning intensity, measured through visual analog scale, and lesion severity based on the Thongprasom scale were assessed weekly for 4 weeks. Descriptive records were kept for side effects and patient satisfaction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pain and burning intensity decreased in both groups throughout the sessions, with the\n                      <jats:italic>N. sativa<\/jats:italic>\n                      group showing a greater reduction than the triamcinolone group. The reduction in burning intensity within each group was significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), and there was a significant difference between groups only in the second session (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.045). The overall difference between groups was not significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u2009.05). Lesion severity also decreased significantly in both groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), with a significant difference between groups observed in the third session (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.043) and overall throughout the study (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The use of\n                      <jats:italic>N. sativa<\/jats:italic>\n                      extract in mucoadhesive patches was as effective as corticosteroids in reducing pain, burning, and lesion severity in patients with oral lichen planus, with\n                      <jats:italic>N. sativa<\/jats:italic>\n                      showing superior results in some sessions. Notably, no significant complications were observed with\n                      <jats:italic>N. sativa<\/jats:italic>\n                      use, making it a promising treatment option for lichen planus.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cre2.886","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T02:19:57Z","timestamp":1716776397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparing the efficacy of a novel mucoadhesive patch containing\n                    <i>Nigella sativa<\/i>\n                    10% with triamcinolone 0.1% in patients with erosive\u2010atrophic oral lichen planus: A pilot study"],"prefix":"10.1002","volume":"10","author":[{"given":"Atessa","family":"Pakfetrat","sequence":"first","affiliation":[{"name":"Oral and Maxillofacial Diseases Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Delavarian","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Diseases Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1095-5260","authenticated-orcid":false,"given":"Mahshid","family":"Malakooti","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, School of Dentistry Mashhad University of Medical Science Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Dental Materials Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habibollah","family":"Esmaily","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Ghorbani","sequence":"additional","affiliation":[{"name":"School of Dentistry Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3213-4110","authenticated-orcid":false,"given":"Pooya","family":"Saeedi","sequence":"additional","affiliation":[{"name":"School of Dentistry Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.32828\/mdj.v6i4.487"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119597797.ch4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2016.3.13006"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.33899\/rden.2010.45402"},{"key":"e_1_2_11_6_1","first-page":"1","article-title":"The various effects of Nigella sativa on multiple body systems in human and animals","volume":"2","author":"Assi M.","year":"2016","journal-title":"Pertanika Jurnal of Schorlarly Research Review"},{"key":"e_1_2_11_7_1","unstructured":"Bagheri H.(2021).Formulation and evaluation of adhesion and mechanical properties of a bilayer mucoadhesive buccal patch for drug delivery system. Mashhad University of Medical sciences."},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0110-5558.76436"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000004314"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.142483"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.139874"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26992"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112135"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-018-8736-8"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3619357"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6189"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-0711-10-29"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6294"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8090342"},{"key":"e_1_2_11_20_1","first-page":"170","article-title":"Polymers in mucoadhesive buccal drug delivery system \u2010 A review","volume":"1","author":"Punitha S.","year":"2010","journal-title":"International Journal of Research in Pharmaceutical Sciences"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10934529.2015.975042"},{"key":"e_1_2_11_22_1","unstructured":"Sarabadani J.(2014).Evaluation of therapeutic effect of Nigella stavia (black seed) oil on erosive atrophic oral lichen planus: A double\u2010blind randomized clinical trial. Mashhad University of Medical Sciences."}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T01:46:31Z","timestamp":1720230391000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,26]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/cre2.886"],"URL":"https:\/\/doi.org\/10.1002\/cre2.886","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,26]]},"assertion":[{"value":"2023-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e886"}}