{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:32:41Z","timestamp":1783413161467,"version":"3.54.6"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T00:00:00Z","timestamp":1716681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate the impact of silver nanoparticles (AgNPs) synthesized from propolis on the formation of <jats:italic>Porphyromonas gingivalis<\/jats:italic> biofilms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>AgNPs were synthesized from propolis, and their inhibitory effect on <jats:italic>P. gingivalis<\/jats:italic> biofilm formation was assessed. Different concentrations of AgNPs (0.1%, 0.3%, and 0.5%) were tested to determine the dose\u2010dependent antibacterial activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of this study indicated that AgNPs exhibited an inhibitory effect on <jats:italic>P. gingivalis<\/jats:italic> biofilm formation. The antibacterial activity of AgNPs was dose\u2010dependent, with concentrations of 0.1%, 0.3%, and 0.5% showing effectiveness. Notably, the concentration of 0.5% demonstrated the most significant anti\u2010biofilm formation activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study suggest that AgNPs synthesized from propolis have potential as an effective option for enhancing periodontal treatment outcomes. The inhibitory effect of AgNPs on <jats:italic>P. gingivalis<\/jats:italic> biofilm formation highlights their potential as alternative antimicrobial agents in the management of periodontal diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.887","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T06:23:34Z","timestamp":1716791014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Green synthesis of silver nanoparticles and evaluation of their effects on the <i>Porphyromonas gingivalis<\/i> bacterial biofilm formation"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1459-0964","authenticated-orcid":false,"given":"Morad","family":"Hedayatipanah","sequence":"first","affiliation":[{"name":"Department of Periodontics, Faculty of Dentistry Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5287-1754","authenticated-orcid":false,"given":"Leila","family":"Gholami","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Faculty of Dentistry Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9671-1696","authenticated-orcid":false,"given":"Abbas","family":"Farmany","sequence":"additional","affiliation":[{"name":"Dental Implant Research Center, Faculty of Dentistry Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1649-7379","authenticated-orcid":false,"given":"Mohammad Yusef","family":"Alikhani","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Infection Disease Research Center Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9567-9607","authenticated-orcid":false,"given":"Amirarsalan","family":"Hooshyarfard","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Dental Material Research Center, Faculty of Dentistry, Tehran Medical Sciences Islamic Azad University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6329-5948","authenticated-orcid":false,"given":"Fahime Sadat","family":"Hashemiyan","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Faculty of Dentistry Qazvin University of Medical Sciences Qazvin Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2021.108647"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10876-019-01697-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.2007.00198.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2010.12.069"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43141-021-00228-w"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/485275"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.100449"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.01.041"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2003275"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4236\/pp.2013.41006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/02726351.2021.1895385"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.01.033"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-12484-y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1049\/nbt2.12078"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S209912"},{"issue":"9","key":"e_1_2_9_17_1","article-title":"Biosynthesis, characterization and antibacterial efficacy of silver nanoparticles derived from endophytic fungi against P. gingivalis","volume":"11","author":"Halkai K. R.","year":"2017","journal-title":"Journal of Clinical and Diagnostic Research: JCDR"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2014.299"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S228396"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.182416"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10015-1639"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9605906"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2013.5989"},{"issue":"2","key":"e_1_2_9_24_1","first-page":"47","article-title":"Analgesic effect of Anatolian propolis in mice","volume":"23","author":"Kamburo\u011flu K.","year":"2011","journal-title":"Agri: Agri (Algoloji) Dernegi'nin Yayin organidir\u2009=\u2009The Journal of the Turkish Society of Algology"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514552491"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2018.12.043"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.4236\/ns.2022.146022"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.04.047"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2014.04.021"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-013-4894-5"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/864729"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1305-8"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-020-00500-4"},{"issue":"3","key":"e_1_2_9_34_1","first-page":"232","article-title":"Prevalence of anaerobic bacteria (P. gingivalis) as major microbial agent in the incidence periodontal diseases by meta\u2010analysis","volume":"19","author":"Rafiei M.","year":"2018","journal-title":"Journal of Dentistry"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.2478\/bjdm-2019-0001"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.5772\/62644"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2020.1858001"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26195762"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/975842"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/215391"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24061033"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2019.10.032"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.11620\/IJOB.2019.44.2.55"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2022.123374"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.30699\/jidai.29.3.119"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-823426-6.00004-8"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10876-019-01732-3"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2008.00966.x"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518758034"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2017.04.005"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T05:46:44Z","timestamp":1720244804000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,26]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/cre2.887"],"URL":"https:\/\/doi.org\/10.1002\/cre2.887","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,26]]},"assertion":[{"value":"2023-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e887"}}