{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:06:24Z","timestamp":1769515584849,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore the antimicrobial potential of strontium (Sr)\u2010functionalized wafers against multiple bacteria associated with per\u2010implant infections, in both mono\u2010 and multispecies biofilms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The bactericidal and bacteriostatic effect of silicon wafers functionalized with a strontium titanium oxygen coating (Sr\u2010Ti\u2010O) or covered only with Ti (controls) against several bacteria, either grown as a mono\u2010species or multispecies biofilms, was assessed using a bacterial viability assay and a plate counting method. Mono\u2010species biofilms were assessed after 2 and 24\u2009h, while the antimicrobial effect on multispecies biofilms was assessed at Days 1, 3, and 6. The impact of Sr functionalization on the total percentage of\u00a0<jats:italic>Porphyromonas gingivalis<\/jats:italic> in the multispecies biofilm, using qPCR, and gingipain activity was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sr\u2010functionalized wafers, compared to controls, were associated with statistically significant less viable cells in both mono\u2010 and multispecies tests. The number of colony forming units (CFUs) within the biofilm was significantly less in Sr\u2010functionalized wafers, compared to control wafers, for <jats:italic>Staphylococcus aureus<\/jats:italic> at all time points of evaluation and for\u00a0<jats:italic>Escherichia coli<\/jats:italic> at Day 1. Gingipain activity was less in Sr\u2010functionalized wafers, compared to control wafers, and the qPCR showed that <jats:italic>P. gingivalis<\/jats:italic> remained below detection levels at Sr\u2010functionalized wafers, while it consisted of 15% of the total biofilm on control wafers at Day 6.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sr functionalization displayed promising antimicrobial potential, possessing bactericidal and bacteriostatic ability against bacteria associated with peri\u2010implantitis grown either as mono\u2010species or mixed in a multispecies consortium with several common oral microorganisms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.903","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T10:53:40Z","timestamp":1721386420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antimicrobial Potential of 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