{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:46:22Z","timestamp":1753868782022,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T00:00:00Z","timestamp":1716681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Periodontitis is an inflammatory condition induced by subgingival bacterial dysbiosis, resulting in inflammatory\u2010mediated destruction of tooth\u2010supporting structures, potentially leading to the formation of infrabony defects. This case report describes the treatment of a patient who presented with a combination 1\u20132\u2010wall defect on tooth 21. To maintain the residual periodontal attachment and minimize esthetic consequences, a regenerative approach was performed using recombinant human platelet\u2010derived growth factor\u2010BB (rh\u2010PDGF\u2010BB) and \u03b2\u2010tricalcium phosphate (\u03b2\u2010TCP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>At the time of postscaling\/root planing reevaluation, a 34\u2010year\u2010old Asian male initially diagnosed with molar\/incisor pattern stage III grade C periodontitis exhibited a 6\u2010mm residual probing depth on the mesiopalatal aspect of tooth 21. Periodontal regenerative surgery was performed using rh\u2010PDGF\u2010BB with \u03b2\u2010TCP, without the use of a membrane.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the 1\u2010year follow\u2010up, a significant reduction in probing depth and radiographic evidence of bone fill were observed. Additionally, re\u2010entry surgery for implant placement at site tooth 23 confirmed bone fill in the defect on tooth 21.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results demonstrate the efficacy of rh\u2010PDGF\u2010BB with \u03b2\u2010TCP in enhancing periodontal regeneration and support its use as a treatment option when treating poorly contained infrabony defects in the esthetic zone.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.908","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T06:05:40Z","timestamp":1716789940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimizing esthetic zone periodontal regeneration in a 1\u20132\u2010wall infrabony defect using recombinant human platelet\u2010derived growth factor BB and \u03b2\u2010tricalcium phosphate: A case report"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5591-0007","authenticated-orcid":false,"given":"Kantapon","family":"Rattanaprukskul","sequence":"first","affiliation":[{"name":"Department of Periodontics, School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Periodontology, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Neiva","sequence":"additional","affiliation":[{"name":"Department of Periodontics, School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Korostoff","sequence":"additional","affiliation":[{"name":"Department of Periodontics, School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,26]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","first-page":"357","article-title":"Biomaterial resorption rate and healing site morphology of inorganic bovine bone and beta\u2010tricalcium phosphate in the canine: A 24\u2010month longitudinal histologic study and morphometric analysis","volume":"19","author":"Artzi Z.","year":"2004","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.22-0361"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.4.261"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120145"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140520"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3785"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2873"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.130685"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1980.tb01952.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514552491"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.1998.tb00701.x"},{"key":"e_1_2_11_13_1","first-page":"1","article-title":"Periodontal regeneration risk assessment in the treatment of intrabony defects","author":"Levine R. 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