{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:18:32Z","timestamp":1772749112289,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:00:00Z","timestamp":1510012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006442","name":"Det Sundhedsvidenskabelige Fakultet, K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006442","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008364","name":"Tandl\u00e6geforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to examine if clinical and histopathological variables in patients with oral lichen planus (OLP), oral lichenoid lesions (OLL), and generalized stomatitis display different cytokine profiles and if concomitant contact allergy influences this profile. Forty\u2010nine patients and 29 healthy age\u2010 and gender\u2010matched subjects were included. Demographic and clinical data immunohistochemical findings in mucosal specimens, results of contact allergy testing, and serum levels of tumor necrosis factor\u2010\u03b1, interferon\u2010\u03b3, interleukin (IL)\u20106, IL\u201010, IL\u201012p40, and IL\u201012p70 were analyzed and compared between groups. Nineteen patients had OLP, primarily with ulcerative lesions on the buccal mucosa, 19 patients had OLL, and 11 patients had generalized stomatitis. All patients had oral symptoms, mainly stinging and burning. Nineteen patients and 10 healthy subjects had contact allergies, primarily to fragrance ingredients. Patient groups did not differ with regard to oral symptoms, clinical pattern of the lesions, or contact allergy. Serum cytokine levels did not differ between the different patient groups and were not related to histopathological findings. The patients had higher levels of IL\u20106 than the healthy subjects. Interferon\u2010\u03b3, IL\u201012p40, and IL\u201012p70 were below detection limit. Our findings indicate that OLP, OLL, and generalized stomatitis cannot be discriminated by means of the selected serum cytokines, and that the presence of concomitant contact allergy does not influence the cytokine expression.<\/jats:p>","DOI":"10.1002\/cre2.91","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T08:35:05Z","timestamp":1510130105000},"page":"220-226","source":"Crossref","is-referenced-by-count":5,"title":["Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4693-0433","authenticated-orcid":false,"given":"Kristine Roen","family":"Larsen","sequence":"first","affiliation":[{"name":"Section for Oral Pathology and Oral Medicine, Department of Odontology, Faculty of Health and Medical Sciences University of Copenhagen  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne Duus","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Gentofte University Hospital  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Reibel","sequence":"additional","affiliation":[{"name":"Section for Oral Pathology and Oral Medicine, Department of Odontology, Faculty of Health and Medical Sciences University of Copenhagen  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Zachariae","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Gentofte University Hospital  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-5803","authenticated-orcid":false,"given":"Anne Marie Lynge","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Section for Oral Pathology and Oral Medicine, Department of Odontology, Faculty of Health and Medical Sciences University of Copenhagen  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12199"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1987.tb00480.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2007.0056"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1990.tb00779.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(00)00139-5"},{"issue":"2","key":"e_1_2_8_7_1","first-page":"157","article-title":"Elevated IL\u201010 concentrations in serum and saliva from patients with oral lichen planus","volume":"42","author":"Dan H.","year":"2011","journal-title":"Quintessence International"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.03.011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152809787582507"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/847632"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.01.020"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000112"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.10.013"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"issue":"4","key":"e_1_2_8_15_1","first-page":"230","article-title":"Detection of T cells secreting type 1 and type 2 cytokines in the peripheral blood of patients with oral lichen planus","volume":"12","author":"Kalogerakou F.","year":"2008","journal-title":"Hippokratia"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2015.41.4.171"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.09-RAI-0136"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.290707.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(78)90383-3"},{"key":"e_1_2_8_20_1","first-page":"103","article-title":"Oral symptoms and salivary findings in oral lichen planus, oral lichenoid lesions and stomatitis","volume":"17","author":"Larsen K. R.","year":"2017","journal-title":"Bio Med Central Oral Health"},{"key":"e_1_2_8_21_1","unstructured":"Larsen K. R. JohansenJ. D. Reibel J. Zachariae C. &Pedersen A. M. (2017).Symptomatic oral lesions may be associated with contact allergy to substances in oral hygiene products. Clinical Oral Investigations Jan 13.https:\/\/doi.org\/10.1007\/s00784\u2010017\u20102053\u2010y. [Epub ahead of print]"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016358809004748"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2013.74"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12142"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.03.018"},{"issue":"3","key":"e_1_2_8_26_1","first-page":"554","article-title":"Salivary Interferon Gamma and Interleukin\u20104 Levels in Patients Suffering from Oral Lichen Planus","volume":"17","author":"Malekzadeh H.","year":"2015","journal-title":"Cell Journal"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2008.00662.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90016-J"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2011.0065"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.00956.x"},{"issue":"2","key":"e_1_2_8_31_1","first-page":"179","article-title":"Expression of interleukin\u201012p40 and interferon\u2010gamma in local lesions of human oral lichen planus","volume":"29","author":"Pan Y. X.","year":"2011","journal-title":"West China Journal of Stomatology"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.08.007"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/09629350410001688530"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12094"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.12.018"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(00)00143-7"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/19854"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411980090010501"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2007.07.199"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(99)00013-8"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2010.00588.x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300405"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1988.tb01527.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00125.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-015-0167-4"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90123-3"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00779.x"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcre2.91","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.91","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T15:19:43Z","timestamp":1696000783000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.91"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,7]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/cre2.91"],"URL":"https:\/\/doi.org\/10.1002\/cre2.91","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,7]]}}}