{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:44:08Z","timestamp":1786653848678,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Sodium hypochlorite solution (NaOCl) is an effective canal irrigant but interferes with the mechanical features of dentin and the bonding capability of adhesives when restoring endodontically treated teeth. This study evaluated whether access cavity resin sealing before using canal irrigant would augment the resistance of endodontically treated anterior teeth against fracture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty maxillary incisors underwent endodontic treatment in five groups (<jats:italic>n<\/jats:italic>\u2009=\u200912). Irrigation with 5.25% NaOCl and 17% ethylenediaminetetraacetic acid (EDTA) was performed in all groups except for Group 5. After root canal obturation, in Group 1, the access cavity was kept unrestored. In Group 2, immediate restoration after obturation was achieved. For Group 3, delayed restoration after 1 week was provided. In Group 4 (pre\u2010sealed), before canal irrigation, the dentin surface of access cavities was sealed using self\u2010adhesive composite resin (Vertise Flow) and then restored after obturation. In Group 5, which was saline irrigated, immediate restoration was performed. After storage and thermal cycling for 5000 cycles at 5\u00b0C\u201355\u00b0C with a dwell time of 15\u2009s and a transfer time of 5\u2009s, teeth were statically loaded by a universal testing machine until a fracture occurred. Data were collected as the fracture resistance (FR) and analyzed using the one\u2010way analysis of variance and Tukey's tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FR significantly differed between all groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The lowest FR was recorded in the unrestored group (284\u2009\u00b1\u200986\u2009N), which was not statistically different from the immediately restored group (<jats:italic>p<\/jats:italic>\u2009=\u20090.065). The pre\u2010sealed group exhibited the highest FR value (810\u2009\u00b1\u2009127\u2009N, <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.02 vs. other groups). The FR of the saline\u2010irrigated and delayed restored groups was almost similar (<jats:italic>p<\/jats:italic>\u2009=\u20090.13).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NaOCl\/EDTA irrigation resulted in an adverse effect on FR. Delayed restoration could reduce this adverse effect. Access cavity pre\u2010sealing with flowable composites led to a higher FR than conventional methods and may be considered an effective step during treatment procedures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.936","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T09:58:54Z","timestamp":1721210334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pre\u2010Sealing of Endodontic Access Cavities for the Preservation of Anterior Teeth Fracture Resistance"],"prefix":"10.1002","volume":"10","author":[{"given":"Fereshteh","family":"Shafiei","sequence":"first","affiliation":[{"name":"Department of Operative Dentistry, School of Dentistry, Oral and Dental Disease Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2221-5531","authenticated-orcid":false,"given":"Maryam S.","family":"Tavangar","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry, School of Dentistry, Oral and Dental Disease Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"issue":"6","key":"e_1_2_11_2_1","first-page":"321","article-title":"Adhesive Sealing of Dentin Surfaces In Vitro: A Review","volume":"28","author":"Abu\u2010Nawareg M. M.","year":"2015","journal-title":"American Journal of Dentistry"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/coatings13010201"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2019-0005"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.jad.a40984"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-03902-y"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.11.010"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2341\/06-104"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aej.12606"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-014-0174-1"},{"issue":"9","key":"e_1_2_11_11_1","first-page":"733","article-title":"Biomechanical Considerations for the Restoration of Endodontically Treated Teeth: A Systematic Review of the Literature\u2014Part 1. Composition and Micro\u2010 and Macrostructure Alterations","volume":"38","author":"Dietschi D.","year":"2007","journal-title":"Quintessence International (Berlin, Germany: 1985)"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.jad.a35257"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2020.103736"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(92)90325-5"},{"issue":"4","key":"e_1_2_11_15_1","first-page":"311","article-title":"Clinical Adhesive Sealing of the Pulp Chamber Following Endodontic Treatment: Influence of Thermomechanical Loading on Microleakage","volume":"11","author":"Ebert J.","year":"2009","journal-title":"The Journal of Adhesive Dentistry"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.14744\/eej.2018.70299"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.jad.a17594"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2015.11.007"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.12.021"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2013.08.001"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.08.008"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpr.2002.124453"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.jad.a33324"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3913(07)60052-3"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2007.01287.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.22635"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595x.2008.tb00354.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-2841"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.04.002"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2018.07.025"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200405000-00013"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2018.01.020"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.2016-137"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2016.04.001"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijadhadh.2018.01.018"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1697412"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/tcrm.S223233"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1987.tb00622.x"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2006.01176.x"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2006.07.001"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.55942"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3913(08)60006-2"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jerd.12100"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13372"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0099-2399(99)80137-x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.jad.a43999"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.jad.a35253"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T09:25:08Z","timestamp":1725009908000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,17]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/cre2.936"],"URL":"https:\/\/doi.org\/10.1002\/cre2.936","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,17]]},"assertion":[{"value":"2023-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e936"}}