{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:37:33Z","timestamp":1781199453906,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp;amp; Exp Dental Res"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to assess the intricate relationship between salivary IgA antibody levels to PAc (361\u2013386) (PPA), mutans streptococci colonization, and root caries development in older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This study included 307 participants aged 76 years residing in Niigata city, Japan. Clinical oral examinations were performed at baseline in 2004 and 1 year later, during which the total number of untreated and treated root caries was assessed using the root decayed, filled tooth (DFT) index. The stimulated saliva samples were collected using the spitting method during the baseline survey. Salivary IgA antibody levels to amino acid residues 361\u2013386 of <jats:italic>Streptococcus mutans<\/jats:italic> PAc were quantified using an enzyme\u2010linked immunosorbent assay. Statistical analyses, including the <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> test, Mann\u2013Whitney <jats:italic>U<\/jats:italic> test, and logistic regressions, were performed to examine the association of increased root DFT with the independent variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 307 participants (53.1% men), the mean root DFT at baseline was 3.77\u2009\u00b1\u20093.66, and 36.5% of the study sample exhibited increased root DFT after 1 year with a mean increment of 0.36\u2009\u00b1\u20090.48. Participants with increase in root DFT after 1 year had significantly higher rates of low PPA levels (\u2264\u200925th percentile) than those without increased root DFT (<jats:italic>p<\/jats:italic>\u2009=\u20090.020). Low PPA levels (\u2264\u200925th percentile) were significantly more likely to have an increased risk of root caries development compared with PPA levels &gt;\u200925th percentile (adjusted OR: 1.88, 95% CI: 1.09\u20133.25).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low PPA levels and root caries incidence correlated significantly, suggesting that low levels of salivary IgA antibody to PAc (361\u2013386) may serve as a risk factor for increased root caries in older adults.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.945","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T05:45:30Z","timestamp":1722923130000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Low Salivary IgA Levels Against PAc (361\u2013386) as a Risk Factor for Root Caries in Older Adults"],"prefix":"10.1002","volume":"10","author":[{"given":"Yu","family":"Ichikawa","sequence":"first","affiliation":[{"name":"Division of Preventive Dentistry, Faculty of Dentistry &amp; 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