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Ni\/Al<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> provided the highest activity, whereas Cu\/Al<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> was the most selective, reaching a 75\u2009% MTHF yield at 250\u2009\u00b0C after 24\u2005h reaction time. Synergetic effects were observed when bimetallic Ni\u2010Cu\/Al<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> catalysts were used, reaching a 56\u2009% MTHF yield in 5\u2005h at 250\u2009\u00b0C for the optimum Ni\/Cu ratio. Remarkably, these high yields were obtained using non\u2010noble metal\u2010based catalysts and 2\u2010propanol as the solvent. The catalytic activity and selectivity results are correlated to temperature programmed reduction (TPR), XRD, and STEM characterization data, identifying the role associated with mixed Ni\u2013Cu particles in addition to monometallic Cu and Ni.<\/jats:p>","DOI":"10.1002\/cssc.201500671","type":"journal-article","created":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T09:37:25Z","timestamp":1441791445000},"page":"3483-3488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["One\u2010Pot 2\u2010Methyltetrahydrofuran Production from Levulinic Acid in Green Solvents Using Ni\u2010Cu\/Al<sub>2<\/sub>O<sub>3<\/sub> Catalysts"],"prefix":"10.1002","volume":"8","author":[{"given":"Iker","family":"Obreg\u00f3n","sequence":"first","affiliation":[{"name":"Chemical and Environmental Engineering Department University of the Basque Country (UPV\/EHU)  Alameda Urquijo s\/n 48013 Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1aki","family":"Gandarias","sequence":"additional","affiliation":[{"name":"Chemical and Environmental Engineering Department University of the Basque Country (UPV\/EHU)  Alameda Urquijo s\/n 48013 Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nemanja","family":"Mileti\u0107","sequence":"additional","affiliation":[{"name":"Chemical and Environmental Engineering Department University of the Basque Country (UPV\/EHU)  Alameda Urquijo s\/n 48013 Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainhoa","family":"Ocio","sequence":"additional","affiliation":[{"name":"Chemical and Environmental Engineering Department University of the Basque Country (UPV\/EHU)  Alameda Urquijo s\/n 48013 Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro L.","family":"Arias","sequence":"additional","affiliation":[{"name":"Chemical and Environmental Engineering Department University of the Basque Country (UPV\/EHU)  Alameda Urquijo s\/n 48013 Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,9]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"C. 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