{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:21:44Z","timestamp":1761513704265,"version":"build-2065373602"},"reference-count":54,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T00:00:00Z","timestamp":1444089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemSusChem"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Applications of the formose reaction, which involves the formation of sugars from formaldehyde, have previously been confined to the selective synthesis of unprotected sugars. Herein, it is demonstrated that \u03b1\u2010hydroxy\u2010\u03b3\u2010butyrolactone (HBL), which is one of the most important intermediates in pharmaceutical syntheses, can be produced from paraformaldehyde. In the developed reaction system, homogeneous tin chloride exhibits high catalytic activity and the addition of mono\u2010 and disaccharides accelerates the formation of HBL. These observations suggest that the formose reaction may serve as a feasible pathway for the synthesis of important chemicals.<\/jats:p>","DOI":"10.1002\/cssc.201500885","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T07:57:20Z","timestamp":1444118240000},"page":"3661-3667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mechanistic Insight into a Sugar\u2010Accelerated Tin\u2010Catalyzed Cascade Synthesis of \u03b1\u2010Hydroxy\u2010\u03b3\u2010butyrolactone from Formaldehyde"],"prefix":"10.1002","volume":"8","author":[{"given":"Sho","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Environmental Chemistry and Engineering Interdisciplinary Graduate School of Science and Engineering Tokyo Institute of Technology  4259-G1-14 Nagatsuta-cho Midori-ku, Yokohama Kanagawa 226-8502 Japan), Fax: (+81)\u2009045-924-5441"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeaki","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Environmental Chemistry and Engineering Interdisciplinary Graduate School of Science and Engineering Tokyo Institute of Technology  4259-G1-14 Nagatsuta-cho Midori-ku, Yokohama Kanagawa 226-8502 Japan), Fax: (+81)\u2009045-924-5441"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Motokura","sequence":"additional","affiliation":[{"name":"Department of Environmental Chemistry and Engineering Interdisciplinary Graduate School of Science and Engineering Tokyo Institute of Technology  4259-G1-14 Nagatsuta-cho Midori-ku, Yokohama Kanagawa 226-8502 Japan), Fax: (+81)\u2009045-924-5441"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuharu","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Environmental Chemistry and Engineering Interdisciplinary Graduate School of Science and Engineering Tokyo Institute of Technology  4259-G1-14 Nagatsuta-cho Midori-ku, Yokohama Kanagawa 226-8502 Japan), Fax: (+81)\u2009045-924-5441"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akimitsu","family":"Miyaji","sequence":"additional","affiliation":[{"name":"Department of Environmental Chemistry and Engineering Interdisciplinary Graduate School of Science and Engineering Tokyo Institute of Technology  4259-G1-14 Nagatsuta-cho Midori-ku, Yokohama Kanagawa 226-8502 Japan), Fax: (+81)\u2009045-924-5441"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihide","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Environmental Chemistry and Engineering Interdisciplinary Graduate School of Science and Engineering Tokyo Institute of Technology  4259-G1-14 Nagatsuta-cho Midori-ku, Yokohama Kanagawa 226-8502 Japan), Fax: (+81)\u2009045-924-5441"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,6]]},"reference":[{"key":"e_1_2_5_1_1","unstructured":"\u00a0"},{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00811770"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijch.201410013"},{"key":"e_1_2_5_4_1","unstructured":"For a one-carbon homologation reaction for example an asymmetric hydroxymethylation see:"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja047896i"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200352724"},{"key":"e_1_2_5_6_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200352724"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol051965w"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200801849"},{"key":"e_1_2_5_8_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200801849"},{"key":"e_1_2_5_9_1","unstructured":"For utilization as an ingredient for polymer products for example Bakelite and urea formaldehyde resin see:"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cber.188401701174"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cber.18960290372"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cber.18960290306"},{"key":"e_1_2_5_13_2","first-page":"460","volume":"21","author":"Goldschmidt C.","year":"1897","journal-title":"Chem. 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