{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T15:52:01Z","timestamp":1789228321157,"version":"build-2803163510"},"reference-count":78,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T00:00:00Z","timestamp":1481673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemSusChem"],"published-print":{"date-parts":[[2017,1,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Catalytic upgrading of 5\u2010hydroxymethylfurfural (HMF), an important biobased platform chemical for high\u2010value products, is currently of great interest. In this work, a new highly HMFtolerant yeast strain\u2014<jats:italic>Meyerozyma guilliermondii<\/jats:italic> SC1103 was isolated, and biocatalytic reduction of HMF to 2,5\u2010bis(hydroxymethyl)furan (BHMF) using its resting cells was reported. Cosubstrates exerted a significant effect on the catalytic activity and selectivity of microbial cells as well as their HMF\u2010tolerant levels whereas the nitrogen source and mineral salts had no effects. In addition, <jats:italic>M.\u2005guilliermondii<\/jats:italic> SC1103 cells exhibited good catalytic performances within the range of pH\u20054.0\u201310.0. The yeast was highly tolerant to both HMF (up to 110\u2005m<jats:sc>m<\/jats:sc>) and BHMF (up to 200\u2005m<jats:sc>m<\/jats:sc>). In addition, 100\u2005m<jats:sc>m<\/jats:sc> HMF could be selectively reduced to BHMF within 12\u2005h by its resting cells in the presence of 100\u2005m<jats:sc>m<\/jats:sc> glucose (as cosubstrate), with a yield of 86\u2009% and selectivity of &gt;99\u2009%. The production of 191\u2005m<jats:sc>m<\/jats:sc> of BHMF was realized within 24.5\u2005h by using a fed\u2010batch strategy, with a productivity of approximately 24\u2005g\u2009<jats:sc>L<\/jats:sc><jats:sup>\u22121<\/jats:sup> per day. In addition, this new biocatalytic approach was applied for the reduction of furfural and 5\u2010methylfurfural, affording the corresponding furfuryl alcohols with yields of 83 and 89\u2009%, respectively.<\/jats:p>","DOI":"10.1002\/cssc.201601426","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T12:51:58Z","timestamp":1481719918000},"page":"372-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":110,"title":["Biocatalytic Reduction of HMF to 2,5\u2010Bis(hydroxymethyl)furan by HMF\u2010Tolerant Whole Cells"],"prefix":"10.1002","volume":"10","author":[{"given":"Yan\u2010Mei","family":"Li","sequence":"first","affiliation":[{"name":"School of Food Science and Engineering South China University of Technology  381 Wushan Road Guangzhou 510640 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering South China University of Technology  381 Wushan Road Guangzhou 510640 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1684-4454","authenticated-orcid":false,"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering South China University of Technology  381 Wushan Road Guangzhou 510640 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering South China University of Technology  381 Wushan Road Guangzhou 510640 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Yong","family":"Lou","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering South China University of Technology  381 Wushan Road Guangzhou 510640 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Hua","family":"Zong","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering South China University of Technology  381 Wushan Road Guangzhou 510640 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,14]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1218930"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cattod.2010.10.100"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1039\/C3GC41935E"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/b922014c"},{"key":"e_1_2_6_6_1","unstructured":"\u00a0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr300182k"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/c0gc00401d"},{"key":"e_1_2_6_9_1","unstructured":"\u00a0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma3023603"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/am405287p"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/bk-1990-0433.ch017"},{"key":"e_1_2_6_13_1","first-page":"763","volume":"73","author":"Matsumoto I.","year":"1973","journal-title":"Jpn. Kokai"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1081\/SCC-120026858"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00829a085"},{"key":"e_1_2_6_16_1","unstructured":"\u00a0"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1039\/C2RA22190J"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc41526k"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4DT00304G"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4GC01127A"},{"key":"e_1_2_6_21_1","unstructured":"\u00a0"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5CY00700C"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.201402095"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5GC01221J"},{"key":"e_1_2_6_25_1","unstructured":"\u00a0"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2011.11.020"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3gc40930a"},{"key":"e_1_2_6_28_1","unstructured":"\u00a0"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.201300443"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.201500176"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5b02586"},{"key":"e_1_2_6_32_1","unstructured":"\u00a0"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2010.09.016"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0958-1669(99)00042-7"},{"key":"e_1_2_6_35_1","unstructured":"\u00a0"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1080\/07328309708006531"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.201200931"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.201200954"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13177"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201402904"},{"key":"e_1_2_6_40_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201402904"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2010.03.050"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5GC00342C"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5GC00707K"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-45209-7_8"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2008.03.004"},{"key":"e_1_2_6_46_1","unstructured":"\u00a0"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2012.08.014"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2015.12.009"},{"key":"e_1_2_6_49_1","unstructured":"\u00a0"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5GC00788G"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.6b00996"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2011.10.007"},{"key":"e_1_2_6_53_1","unstructured":"\u00a0"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8524(99)00161-3"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2003.10.005"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2016.04.122"},{"key":"e_1_2_6_57_1","unstructured":"\u00a0"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-004-0148-3"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbt.2011.09.001"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1385\/ABAB:121:1-3:0451"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2013.04.122"},{"key":"e_1_2_6_62_1","unstructured":"\u00a0"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bej.2013.01.003"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13068-015-0244-9"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/1754-6834-7-51"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-014-5802-8"},{"key":"e_1_2_6_67_1","unstructured":"\u00a0"},{"key":"e_1_2_6_68_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3630769"},{"key":"e_1_2_6_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0290(19991005)65:1<24::AID-BIT4>3.0.CO;2-2"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/jctb.1676"},{"key":"e_1_2_6_71_1","unstructured":"\u00a0"},{"key":"e_1_2_6_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcata.2006.09.037"},{"key":"e_1_2_6_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0926-860X(02)00140-0"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/0141-0229(88)90135-4"},{"key":"e_1_2_6_75_1","unstructured":"\u00a0"},{"key":"e_1_2_6_76_2","first-page":"641","volume":"11","author":"Lee S. S.","year":"1981","journal-title":"Biotechnol. Bioeng.."},{"key":"e_1_2_6_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2015.02.089"}],"container-title":["ChemSusChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcssc.201601426","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cssc.201601426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:25:26Z","timestamp":1760383526000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cssc.201601426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,14]]},"references-count":78,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,1,20]]}},"alternative-id":["10.1002\/cssc.201601426"],"URL":"https:\/\/doi.org\/10.1002\/cssc.201601426","archive":["Portico"],"relation":{},"ISSN":["1864-5631","1864-564X"],"issn-type":[{"value":"1864-5631","type":"print"},{"value":"1864-564X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,14]]},"assertion":[{"value":"2016-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}