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Precious metal catalysts are highly active for the catalytic oxidation of VOCs, but they are rare and their high price limits large\u2010scale application. Supported metal single\u2010atom catalysts (SACs) have a high atom efficiency and provide the possibility to circumvent such limitations. This Review summarizes recent advances in the use of metal SACs for the complete oxidation of VOCs, such as benzene, toluene, formaldehyde, and methanol, as well as aliphatic and Cl\u2010 and S\u2010containing hydrocarbons. The structures of the metal SACs used and the reaction mechanisms of the VOC oxidation are discussed. The most widely used SACs are noble metals supported on oxides, especially on reducible oxides, such as Mn<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub> and TiO<jats:sub>2<\/jats:sub>. The reactivity of most SACs is related to the activity of surface lattice oxygen of the oxides. Furthermore, several metal SACs show better reactivity and improved S and Cl resistance than the corresponding nanocatalysts, indicating that SACs have potential for application in the oxidation of VOCs. The deactivation and regeneration mechanisms of the metal SACs are also summarized. It is concluded that the application of metal SACs in catalytic oxidation of VOCs is still in its infancy. This Review aims to elucidate structure\u2013performance relationships and to guide the design of highly efficient metal SACs for the catalytic oxidation of VOCs.<\/jats:p>","DOI":"10.1002\/cssc.202102494","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T05:10:40Z","timestamp":1642655440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Noble Metal Single\u2010Atom Catalysts for the Catalytic Oxidation of Volatile Organic Compounds"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3564-9961","authenticated-orcid":false,"given":"Lina","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering Xiamen University  Xiamen 361005 P. R. 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