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However, many catalysts for these reactions use environmentally unfriendly solvents that include dichloromethane, chloroform, 1,2\u2010dichloroethane and benzene. We developed a high\u2010throughput experimentation (HTE) protocol for heterogeneous NT reaction mixtures to enable rapid screening of a broad range of solvents for this chemistry. Coupled with the American Chemical Society Pharmaceutical Roundtable (ACSPR) solvent tool, we identified several attractive replacements for chlorinated solvents. Selected catalysts for NT were compared and contrasted using our HTE protocol, including silver supported by <jats:italic>N<\/jats:italic>\u2010dentate ligands, dinuclear Rh complexes and Fe\/Mn phthalocyanine catalysts.<\/jats:p>","DOI":"10.1002\/cssc.202300964","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T22:46:33Z","timestamp":1694472393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Solvent Effects on the Chemo\u2010 and Site\u2010Selectivity of Transition Metal\u2010Catalyzed Nitrene Transfer Reactions: Alternatives to Chlorinated Solvents**"],"prefix":"10.1002","volume":"17","author":[{"given":"Robert M.","family":"Ward","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Wisconsin 1101 University Avenue  Madison WI 53706 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Wisconsin 1101 University Avenue  Madison WI 53706 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah P.","family":"Tu","sequence":"additional","affiliation":[{"name":"Discovery Chemistry and Technology AbbVie Inc.  1\u2005N. Waukegan Rd. North Chicago Illinois 60064 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1329-950X","authenticated-orcid":false,"given":"Jennifer M.","family":"Schomaker","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Wisconsin 1101 University Avenue  Madison WI 53706 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"key":"e_1_2_11_1_1","unstructured":"For selected reviews on transition metal-catalyzed nitrene transfer 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