{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:37:55Z","timestamp":1786977475678,"version":"build-2736575974"},"reference-count":98,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21801149"],"award-info":[{"award-number":["21801149"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemSusChem"],"published-print":{"date-parts":[[2024,5,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>New methods and strategies for the direct oxidation of benzylic C\u2212H bonds are highly desirable, owing to the importance of ketone motifs in significant organic transformations and the synthesis of valuable molecules, including pharmaceuticals, pesticides, and fine chemicals. Herein, we describe an electrochemical benzylic C\u2212H oxidation strategy for the synthesis of ketones using MeOH as an oxygen source. Inexpensive and safe KBr serves as both an electrolyte and a bromide radical precursor in the reaction. This transformation also offers several advantages such as mild conditions, broad functional group tolerance, and operational simplicity. Mechanistic investigations by control experiments, radical scavenging experiments, electron paramagnetic resonance (EPR), kinetic studies, cyclic voltammetry (CV), and in\u2010situ Fourier transform infrared (FTIR) spectroscopy support a pathway involving the formation and transformation of benzyl methyl ether via hydrogen atom transfer (HAT) and single\u2010electron transfer (SET). The practical application of our strategy is highlighted by the successful synthesis of five pharmaceuticals, namely lenperone, melperone, diphenhydramine, cinnarizine, and flunarizine.<\/jats:p>","DOI":"10.1002\/cssc.202400028","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T22:40:05Z","timestamp":1705358405000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sustainable Electrochemical Benzylic C\u2212H Oxidation Using MeOH as an Oxygen Source"],"prefix":"10.1002","volume":"17","author":[{"given":"Meng","family":"Xue","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering Qingdao University  308 Ningxia Road Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Qingdao University  308 Ningxia Road Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Shao","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Qingdao University  308 Ningxia Road Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Ecology and Environment Ningxia University  489 Helan Mountain West Road Yinchuan 750021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Ecology and Environment Ningxia University  489 Helan Mountain West Road Yinchuan 750021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixing","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Qingdao University  308 Ningxia Road Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Qingdao University  308 Ningxia Road Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2489-1253","authenticated-orcid":false,"given":"Yuexia","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Qingdao University  308 Ningxia Road Qingdao 266071 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