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An example for such a power\u2010to\u2010chemicals process is the industrial\u2010scale fermentation for the production of hexanoic acid. Herein, we describe how this product is transformed into 6\u2010undecanone via decarboxylative ketonization using a heterogeneous manganese oxide\/silica catalyst. The reaction reaches full conversion with near\u2010complete selectivity when carried out in a continuous flow reactor, requires no solvent or carrier gas, and releases carbon dioxide and water as the only by\u2010products. The reactor was operated for several weeks with no loss of reactivity, producing 7\u2005kg of 6\u2010undecanone from 10\u2005g of catalyst and achieving a productivity of 1.135\u2005kg per litre of reactor volume per hour. 6\u2010Undecanone and other long\u2010chain ketones accessible this way can be hydrogenated to industrially meaningful alkanes, or converted into valuable fatty acids via a hydrogenation\/elimination\/isomerizing hydrocarboxylation sequence.<\/jats:p>","DOI":"10.1002\/cssc.202400094","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T14:43:58Z","timestamp":1713451438000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Decarboxylative Ketonization of Aliphatic Carboxylic Acids in a Continuous Flow Reactor Catalysed by Manganese Oxide on Silica"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2682-0010","authenticated-orcid":false,"given":"Jonas F.","family":"Goebel","sequence":"first","affiliation":[{"name":"Chair of Organic Chemistry I Department of Chemistry and Biochemistry Ruhr University Bochum  Universit\u00e4tsstr. 150 44801 Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Belitz","sequence":"additional","affiliation":[{"name":"Chair of Organic Chemistry I Department of Chemistry and Biochemistry Ruhr University Bochum  Universit\u00e4tsstr. 150 44801 Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Sowa","family":"Prendes","sequence":"additional","affiliation":[{"name":"Chair of Organic Chemistry I Department of Chemistry and Biochemistry Ruhr University Bochum  Universit\u00e4tsstr. 150 44801 Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannik","family":"Haver","sequence":"additional","affiliation":[{"name":"Laboratory of Industrial Chemistry Department of Chemistry and Biochemistry Ruhr University Bochum  Universit\u00e4tsstr. 150 44801 Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Diehl","sequence":"additional","affiliation":[{"name":"Laboratory of Industrial Chemistry Department of Chemistry and Biochemistry Ruhr University Bochum  Universit\u00e4tsstr. 150 44801 Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5343-6922","authenticated-orcid":false,"given":"Martin","family":"Muhler","sequence":"additional","affiliation":[{"name":"Laboratory of Industrial Chemistry Department of Chemistry and Biochemistry Ruhr University Bochum  Universit\u00e4tsstr. 150 44801 Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2547-3037","authenticated-orcid":false,"given":"Lukas J.","family":"Goo\u00dfen","sequence":"additional","affiliation":[{"name":"Chair of Organic Chemistry I Department of Chemistry and Biochemistry Ruhr University Bochum  Universit\u00e4tsstr. 150 44801 Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,18]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"\u00a0"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr068360d"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11475"},{"key":"e_1_2_9_4_1","unstructured":"M.\u2005U. 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