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The shortage of agrochemicals due to consumer perception, changing needs of farmers and ever\u2010changing regulatory requirements is higher than the number of active ingredients that are placed on the market. The introduction of halogen atoms into an active ingredient molecule offers the opportunity to optimize its physico\u2010chemical properties such as molecular lipophilicity. As early as 2010, around four\u2010fifths of modern agrochemicals on the market contained halogen atoms. In addition, it becomes clear that modern agrochemicals have increasingly complex molecular structures with one or more stereogenic centers in the molecule. Today, almost half of modern agrochemicals are chiral molecules (herbicides, insecticides\/acaricides\/nematicides \u226a fungicides) and most of them consist of mixtures such as racemic mixtures of enantiomers, followed by mixtures of diastereomers and mixtures of pure enantiomers. Therefore, it is important that halogen\u2010containing substituents or stereogenic centers are considered in the structural optimization of the active ingredients to ultimately develop sustainable agrochemicals in terms of efficacy, ecotoxicology, ease of use and cost\u2010effectiveness.<\/jats:p>","DOI":"10.1002\/cssc.202401042","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T08:39:54Z","timestamp":1728290394000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["New Active Ingredients for Sustainable Modern Chemical Crop Protection in Agriculture"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6369-093X","authenticated-orcid":false,"given":"Peter","family":"Jeschke","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry and Macromolecular Chemistry Heinrich Heine University D\u00fcsseldorf  University Street 1 D-40225 Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"e_1_2_5_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527655908.ch4"},{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202101513"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","unstructured":"P. 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