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The reported synthesis of this probe fell short in the aspects of greenness and economy due to the involvement of toxic Chromium(IV) oxidant, noble palladium catalyst, elevated reaction temperature, the long reaction time as well as the cumbersome workup. Herein, a holistic optimization of the synthetic process was achieved via the employment of flow technology and heterogenous photocatalysis. Firstly, the integration of heterogenous carbon nitrides photocatalysis and circulation flow technology furnished the air oxidation of alcohol and nickel catalyzed C\u2212N coupling at 20\u2005g scale, thus avoiding the use of toxic Chromium and precious palladium species respectively. Flow\u2010intensified esterification between acyl chloride and alcohol, just taking 30\u2005seconds replaced the Steglich esterification of 6\u2005hours, also avoiding the generation of difficult\u2010to\u2010remove dicyclohexylurea. Finally, C\u2212N coupling, esterification and Knoevenagel condensation were telescoped together, thus simplifying the reaction workup. This fully\u2010flow protocol led to the on\u2010demand synthesis of eight probes.<\/jats:p>","DOI":"10.1002\/cssc.202401214","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T10:44:32Z","timestamp":1721385872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Green Synthesis of Alzheimer\u2032s Disease Probes Aftobetin and Analogues Enabled by Flow Technology and Heterogeneous Photocatalysis"],"prefix":"10.1002","volume":"18","author":[{"given":"Yongjiu","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Science and Technology College of Chemistry Fuzhou University  Fuzhou 350108 China"},{"name":"Qingyuan Innovation Laboratory  Quanzhou 362801 China"},{"name":"Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University) Fuzhou University  Fuzhou 350108 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