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Despite their high importance, the sustainable and cost\u2010effective synthesis of organophoshoryl derivatives remains very challenging. Here, we report the first successful regio\u2010 and stereoselective hydrophosphorylation of terminal allenamides using an affordable copper catalyst system. This reaction offers an efficient protocol for the synthesis of (<jats:italic>E<\/jats:italic>)\u2010allylic organophosphorus derivatives from various types of <jats:italic>P<\/jats:italic>\u2010nucleophiles, such as <jats:italic>H<\/jats:italic>\u2010phosphonates, <jats:italic>H<\/jats:italic>\u2010phosphinates, and secondary phosphine oxides. Key advantages of this ligand\u2010free and atom\u2010economic strategy include low toxicity of the Cu\u2010based catalyst, cost effectiveness, mild reaction conditions, and experimental simplicity, making it competitive with methods that use toxic and expensive Pd\u2010based catalysts. In an effort to comprehend this process, we conducted extensive DFT calculations on this system to uncover the mechanistic insights of this process.<\/jats:p>","DOI":"10.1002\/cssc.202401450","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T11:42:37Z","timestamp":1724931757000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Copper\u2010Catalysed Synthesis of (<i>E<\/i>)\u2010Allylic Organophosphorus Derivatives: A Low Toxic, Mild, Economical, and Ligand\u2010Free Method"],"prefix":"10.1002","volume":"18","author":[{"given":"Lucas","family":"Pag\u00e8s","sequence":"first","affiliation":[{"name":"ICGM Universit\u00e9 Montpellier, CNRS, ENSCM  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gracjan","family":"Kurpik","sequence":"additional","affiliation":[{"name":"Center for Advanced Technologies Adam Mickiewicz University in Pozna\u0144  Uniwersytetu Pozna\u0144skiego 10 61-614 Pozna\u0144 Poland"},{"name":"Faculty of Chemistry Adam Mickiewicz University in Pozna\u0144  Uniwersytetu Pozna\u0144skiego 8 61-614 Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Mollfulleda","sequence":"additional","affiliation":[{"name":"IQCC and Department of Chemistry Universitat de Girona  c\/M.A. Capmany 69 17003 Girona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Racha Abed Ali","family":"Abdine","sequence":"additional","affiliation":[{"name":"ICGM Universit\u00e9 Montpellier, CNRS, ENSCM  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Walczak","sequence":"additional","affiliation":[{"name":"Center for Advanced Technologies Adam Mickiewicz University in Pozna\u0144  Uniwersytetu Pozna\u0144skiego 10 61-614 Pozna\u0144 Poland"},{"name":"Faculty of Chemistry Adam Mickiewicz University in Pozna\u0144  Uniwersytetu Pozna\u0144skiego 8 61-614 Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Monnier","sequence":"additional","affiliation":[{"name":"ICGM Universit\u00e9 Montpellier, CNRS, ENSCM  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Swart","sequence":"additional","affiliation":[{"name":"IQCC and Department of Chemistry Universitat de Girona  c\/M.A. Capmany 69 17003 Girona Spain"},{"name":"ICREA  Passeig Llu\u00eds Companys 23 08010 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur R.","family":"Stefankiewicz","sequence":"additional","affiliation":[{"name":"Center for Advanced Technologies Adam Mickiewicz University in Pozna\u0144  Uniwersytetu Pozna\u0144skiego 10 61-614 Pozna\u0144 Poland"},{"name":"Faculty of Chemistry Adam Mickiewicz University in Pozna\u0144  Uniwersytetu Pozna\u0144skiego 8 61-614 Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2991-5418","authenticated-orcid":false,"given":"Marc","family":"Taillefer","sequence":"additional","affiliation":[{"name":"ICGM Universit\u00e9 Montpellier, CNRS, ENSCM  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.166.3901.122"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201800693"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar800221e"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2016.01.012"},{"key":"e_1_2_7_5_1","unstructured":"L.\u2005D. 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