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In this work, we studied the inulin conversion into 5\u2010hydroxymethylfurfural, in deep eutectic solvents, in the presence of acidic task\u2010specific ionic liquids as catalysts. We employed aliphatic and aromatic ionic liquids as catalysts, and choline chloride\u2010based deep eutectic solvents bearing glycols or carboxylic acids, as solvents. The reactions were performed in a biphasic system, with acetone as a benign extracting solvent, enabling continuous extraction of 5\u2010HMF. We aimed to find the best experimental conditions for this transformation, in terms of catalyst loading, solvent, reaction time and temperature to achieve an economical and energy efficient process. We also analyzed the results in terms of solvent viscosity and structural organization as well as catalysts acidity, to elucidate which structural features mostly favour the reaction. Under optimized conditions, we obtained a yield in 5\u2010HMF of 71\u2009%, at 80\u2009\u00b0C in 3\u2005h. Our system can be scaled up and recycled three times with no loss in yield. Finally, comparison with the literature shows that our system achieves a higher yield under milder conditions than most protocols so far reported for the same transformation.<\/jats:p>","DOI":"10.1002\/cssc.202402522","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T11:55:51Z","timestamp":1737719751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inulin Dehydration to 5\u2010HMF in Deep Eutectic Solvents Catalyzed by Acidic Ionic Liquids Under Mild Conditions"],"prefix":"10.1002","volume":"18","author":[{"given":"Salvatore","family":"Marullo","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Biologiche, Chimiche e Farmaceutiche Universit\u00e0 degli Studi di Palermo  Viale delle Scienze, Ed.\u200517 90128 Palermo Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Raia","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biologiche, Chimiche e Farmaceutiche Universit\u00e0 degli Studi di Palermo  Viale delle Scienze, Ed.\u200517 90128 Palermo Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh J.","family":"Bailey","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Queen's University Belfast  Belfast BT9 5AG, Northern Ireland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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