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The RAM approach demonstrated advantages over traditional solution\u2010based methods by enhancing sustainability and minimizing solvent usage. The processes are assessed by green chemistry metrics and tools (e.g., Chem21 and DOZN 3.0) demonstrating that RAM technology is outperforming compared to the corresponding solution\u2010based methods, representing an environmentally friendly alternative to conventional approaches in organic synthesis and for the preparation of pharmaceuticals in a more sustainable way. 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