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In this study, a novel, metal\u2010free bis(trifluoroacetoxy)iodo]benzene\u2010mediated strategy for the regioselective C5\u2010sulfenylation of imidazo[2,1\u2010\n                    <jats:italic>b<\/jats:italic>\n                    ]thiazoles using aryl methyl sulfides under mechanochemical conditions is reported. This solvent\u2010free approach offers a rapid, efficient, and environmentally friendly alternative to current methods, achieving yields of up to 86% while completely avoiding hazardous solvents. The method exhibits broad substrate scope, with tolerance to both electron\u2010donating and electron\u2010withdrawing functional groups. This mechanochemical strategy provides a valuable synthetic tool for the functionalization of imidazo[2,1\u2010\n                    <jats:italic>b<\/jats:italic>\n                    ]thiazole scaffold, with potential applications in medicinal and materials chemistry.\n                  <\/jats:p>","DOI":"10.1002\/cssc.202500320","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T09:27:40Z","timestamp":1745832460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mechanochemical Approach for Metal\u2010Free Regioselective C5\u2010Sulfenylation of Imidazo[2,1\u2010\n                    <i>b<\/i>\n                    ]Thiazoles"],"prefix":"10.1002","volume":"18","author":[{"given":"Xinya","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Chemistry, CNRS, BioCIS Universit\u00e9 Paris\u2010Saclay  91400 Orsay 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