{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:14:11Z","timestamp":1791342851663,"version":"4.3.1"},"reference-count":63,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014810","name":"Fondazione di Sardegna","doi-asserted-by":"publisher","award":["F73C23001600007"],"award-info":[{"award-number":["F73C23001600007"]}],"id":[{"id":"10.13039\/100014810","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemSusChem"],"published-print":{"date-parts":[[2025,8,6]]},"abstract":"<jats:p>Thalassemias are a group of inherited hemoglobinopathies that disrupt normal hemoglobin synthesis. Managing these conditions often involves regular blood transfusions and iron chelation therapy to mitigate iron overload. Among the available chelators, deferoxamine, deferasirox, and deferiprone, the latter stands out notably for its use when other drugs are ineffective or intolerable for patients. Although the synthesis of deferiprone is well\u2010documented, traditional methods typically involve lengthy reaction times and environmentally harmful conditions. This study investigates mechanochemistry as a more sustainable, efficient, and eco\u2010friendly alternative. Deferiprone is successfully synthesized and the production process is optimized by employing solid\u2010state techniques, thereby reducing reaction time, energy consumption, and environmental impact. These findings pave the way for cleaner and more sustainable manufacturing pathways for this critical agent in thalassemia management.<\/jats:p>","DOI":"10.1002\/cssc.202500457","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T10:19:13Z","timestamp":1750933153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Beyond Simple Grinding: Methylammonium Chloride Promotes Sustainable, Cylinder\u2010Free Mechanochemical Synthesis of Deferiprone"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5480-1044","authenticated-orcid":false,"given":"Francesco","family":"Basoccu","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Chimiche e Geologiche Universit\u00e0 degli Studi di Cagliari Cittadella Universitaria Monserrato  S.P. Monserrato\u2010Sestu Km 0,700 09042 Monserrato CA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Piermarini","sequence":"additional","affiliation":[{"name":"Centro Ricerche\u2010Chiesi Farmaceutici S.p.A  Largo Belolli 11\/a 43126 Parma PR Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Angelini","sequence":"additional","affiliation":[{"name":"Centro Ricerche\u2010Chiesi Farmaceutici S.p.A  Largo Belolli 11\/a 43126 Parma PR Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Mari","sequence":"additional","affiliation":[{"name":"Centro Ricerche\u2010Chiesi Farmaceutici S.p.A  Largo Belolli 11\/a 43126 Parma PR Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Mariani","sequence":"additional","affiliation":[{"name":"Centro Ricerche\u2010Chiesi Farmaceutici S.p.A  Largo Belolli 11\/a 43126 Parma PR Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Falchi","sequence":"additional","affiliation":[{"name":"Centro Ricerche\u2010Chiesi Farmaceutici S.p.A  Largo Belolli 11\/a 43126 Parma PR Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7367-1102","authenticated-orcid":false,"given":"Andrea","family":"Porcheddu","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche e Geologiche Universit\u00e0 degli Studi di Cagliari Cittadella Universitaria Monserrato  S.P. Monserrato\u2010Sestu Km 0,700 09042 Monserrato CA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-11"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1179\/102453312X13336169155295"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200203000-00007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181fcb468"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5958\/2231-5691.2018.00034.5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21826"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200011000-00022"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.19082\/4003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(12)70003-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181cd68ed"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1788"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(66)90039-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01416.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.11.29"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000057633"},{"key":"e_1_2_8_17_1","first-page":"12","volume":"51","author":"Tar\u0131m H.","year":"2022","journal-title":"Iran. J. Public Health"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23405"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12413"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228771"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2019.01.003"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409013310902"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199106010-00004"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(08)70007-9"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic00003a031"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11243-015-9912-7"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic202004d"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05586.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1867"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02724272"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000040949"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1693(00)85549-8"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf00027a002"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01112854"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1071\/CH9761329"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi1947.90.10_1222"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00091a033"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b06296"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/B918439B"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1139\/v88-019"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c03833"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1CS15171A"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CC04929A"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.202100478"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00997H"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287399109531485"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3109\/08958379009145243"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202400425"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.202301034"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201810902"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2085-3410"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC05371A"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4GC00699B"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC04487B"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201501371"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.6b00277"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.202402547"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.7b03260"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00813A"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5MR90005K"},{"key":"e_1_2_8_61_1","unstructured":"See section 2 in the ESI file for further details."},{"key":"e_1_2_8_62_1","unstructured":"For a further analysis of the reaction time please refer to Section 3 in the ESI file."},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1DT11677K"},{"key":"e_1_2_8_64_1","unstructured":"For further details concerning the protocol employed please refer to Section 7 in the ESI file."}],"container-title":["ChemSusChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cssc.202500457","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cssc.202500457","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cssc.202500457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:48:27Z","timestamp":1780562907000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cssc.202500457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":63,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,8,6]]}},"alternative-id":["10.1002\/cssc.202500457"],"URL":"https:\/\/doi.org\/10.1002\/cssc.202500457","archive":["Portico"],"relation":{},"ISSN":["1864-5631","1864-564X"],"issn-type":[{"value":"1864-5631","type":"print"},{"value":"1864-564X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,14]]},"assertion":[{"value":"2025-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500457"}}