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Nonetheless, the reliance on highly pressurized canisters and specialized equipment limits its practical application in fine chemical synthesis. This study explores the innovative use of sodium bicarbonate (NaHCO\n                    <jats:sub>3<\/jats:sub>\n                    ) as a safe, solid, on\u2010demand source of CO\n                    <jats:sub>2<\/jats:sub>\n                    under mechanochemical conditions to perform carboxylation reactions. Two applications of the practical mechanochemical syntheses using sodium bicarbonate are developed: first, the synthesis of cyclic carbamates from propargylic amines is investigated, and second, cyclic organic carbonates are derived from epoxides. The potential of this approach in the pharmaceutical industry is further showcased by demonstrating the solvent\u2010minimized synthesis of pharmaceutically relevant molecules and introducing a\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010labeling strategy utilizing NaH\n                    <jats:sup>13<\/jats:sup>\n                    CO\n                    <jats:sub>3<\/jats:sub>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/cssc.202500461","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T12:23:59Z","timestamp":1746707039000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Mechanochemical Activation of NaHCO\n                    <sub>3<\/sub>\n                    : A Solid CO\n                    <sub>2<\/sub>\n                    Surrogate in Carboxylation Reactions"],"prefix":"10.1002","volume":"18","author":[{"given":"Francesco","family":"Mele","sequence":"first","affiliation":[{"name":"SynCat Lab Department of Chemistry Life Sciences and Environmental Sustainability (SCVSA) University of Parma  Parco Area delle Scienze, 17\/A 43124 Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Aquilini","sequence":"additional","affiliation":[{"name":"SynCat Lab Department of Chemistry Life Sciences and Environmental Sustainability (SCVSA) University of Parma  Parco Area delle Scienze, 17\/A 43124 Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Constantin","sequence":"additional","affiliation":[{"name":"SynCat Lab Department of Chemistry Life Sciences and Environmental Sustainability (SCVSA) University of Parma  Parco Area delle Scienze, 17\/A 43124 Parma 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Department of Chemistry Life Sciences and Environmental Sustainability (SCVSA) University of Parma  Parco Area delle Scienze, 17\/A 43124 Parma Italy"},{"name":"CIRCC (Interuniversity Consortium Chemical Reactivity and Catalysis)  Via Celso Ulpiani 27 Bari 70126 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele Alessandro","family":"Cauzzi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Life Sciences and Environmental Sustainability (SCVSA) University of Parma  Parco Area delle Scienze, 17\/A 43124 Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Maestri","sequence":"additional","affiliation":[{"name":"Department of Chemistry Life Sciences and Environmental Sustainability (SCVSA) University of Parma  Parco Area delle Scienze, 17\/A 43124 Parma Italy"},{"name":"CIRCC (Interuniversity Consortium Chemical Reactivity and Catalysis)  Via Celso Ulpiani 27 Bari 70126 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Motti","sequence":"additional","affiliation":[{"name":"SynCat Lab Department of Chemistry Life Sciences and Environmental Sustainability (SCVSA) University of Parma  Parco Area delle Scienze, 17\/A 43124 Parma Italy"},{"name":"CIRCC (Interuniversity Consortium Chemical Reactivity and Catalysis)  Via Celso Ulpiani 27 Bari 70126 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Capaldo","sequence":"additional","affiliation":[{"name":"SynCat Lab Department of Chemistry Life Sciences and Environmental Sustainability (SCVSA) University of Parma  Parco Area delle Scienze, 17\/A 43124 Parma Italy"},{"name":"CIRCC (Interuniversity Consortium Chemical Reactivity and Catalysis)  Via Celso Ulpiani 27 Bari 70126 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an isolable organic compound generated during the reaction likely arising from epoxide ring\u2010opening and the formation of the corresponding alkoxide. The alkoxide quickly reacts with CO2to form the final carbonateviaa carboxylative cyclization. As we have demonstrated 28'also provides the final product although at a slower rate compared to the more reactive non\u2010isolable alkoxide."},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8GC03086C"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.9b01234"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26216453"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/00986448508911162"},{"key":"e_1_2_7_68_1","unstructured":"In the synthesis of cyclic carbonates which is not compatible with the presence ofG the supposedin\u2009situgeneration of CO2may be reasonably slower and this may explain the larger amount of NaHCO3required (20\u2009equiv.vs8\u2009equiv)."},{"key":"e_1_2_7_69_1","unstructured":"Upon reaction completion the crude mixture was recovered with ethyl acetate and the residual solids were filtered and washed with DCM (15\u2009mL\u2009\u00d7\u20093) until all organic substances were removed. 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