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The acidic eutectic mixture ChCl<jats:italic>\/p\u2010<\/jats:italic>TSA\u00b7H<jats:sub>2<\/jats:sub>O (1:2) (ChCl\u2009=\u2009choline chloride; <jats:italic>p<\/jats:italic>\u2010TSA\u2009=\u2009<jats:italic>p<\/jats:italic>\u2010toluenesulfonic acid) serves as both promoter and reaction medium. This transformation involves a cascade process comprising three consecutive steps: i) hydration of terminal alkynes to methyl ketones; ii) Claisen\u2013Schmidt condensation with aldehydes, and iii) sulfa\u2010Michael or phospha\u2010Michael additions using sodium sulfinates or secondary phosphine oxides, respectively. The methodology provides high yields (up to 99%), excellent atom economy, and operational simplicity, as the products are isolated without the use of any toxic volatile organic solvents or tedious chromatographic purification. Its modular nature accommodates a broad range of substrates, including electron\u2010rich and electron\u2010deficient components, demonstrating robustness and versatility (112 examples). Furthermore, the protocol enables scalable (tenfold) and recyclable (five cycles) synthesis of biologically relevant <jats:italic>\u03b3<\/jats:italic>\u2010keto derivatives under green conditions (<jats:italic>E<\/jats:italic>\u2010factor\u2009\u2264\u200910), offering a general strategy for sustainable and modular C\uf8ffC and C\uf8ffX bond\u2010forming reactions.<\/jats:p>","DOI":"10.1002\/cssc.202500679","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T05:37:39Z","timestamp":1749015459000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Modular, Tricomponent, and Concurrent One\u2010Pot Synthesis of Libraries of <i>\u03b3<\/i>\u2010Keto Sulfones and <i>\u03b3<\/i>\u2010Keto Phosphine Oxides using Br\u00f8nsted Acidic Eutectic Mixtures"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7014-0725","authenticated-orcid":false,"given":"Marina","family":"Ramos\u2010Mart\u00edn","sequence":"first","affiliation":[{"name":"Laboratorio de Qu\u00edmica Sint\u00e9tica Sostenible (QuimSinSos) Departamento de Qu\u00edmica Org\u00e1nica e Inorg\u00e1nica, (IUQOEM) Facultad de Qu\u00edmica Centro de Innovaci\u00f3n en Qu\u00edmica Avanzada (ORFEO\u2010CINQA) Universidad de Oviedo  E33071 Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2266-744X","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Garc\u00eda\u2010\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica Sint\u00e9tica Sostenible (QuimSinSos) Departamento de Qu\u00edmica Org\u00e1nica e Inorg\u00e1nica, (IUQOEM) Facultad de Qu\u00edmica Centro de Innovaci\u00f3n en Qu\u00edmica Avanzada (ORFEO\u2010CINQA) Universidad de Oviedo  E33071 Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3565-4672","authenticated-orcid":false,"given":"Alejandro","family":"Presa Soto","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica Sint\u00e9tica Sostenible (QuimSinSos) Departamento de Qu\u00edmica Org\u00e1nica e Inorg\u00e1nica, (IUQOEM) Facultad de Qu\u00edmica Centro de Innovaci\u00f3n en Qu\u00edmica Avanzada (ORFEO\u2010CINQA) Universidad de Oviedo  E33071 Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b12408"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1589-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2007.10.045"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar000034b"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202203512"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901241e"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2md20347b"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/op060170h"},{"key":"e_1_2_7_10_1","volume-title":"Green Chemistry Theory And Practice","author":"Anastas P. 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