{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:39:42Z","timestamp":1786977582441,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemSusChem"],"published-print":{"date-parts":[[2025,7,27]]},"abstract":"<jats:p>\n                    Regiodivergent reduction of epoxides under mild conditions is highly attractive for selective functionalization in organic synthesis. Notwithstanding the advances in methanol as an H\n                    <jats:sub>2<\/jats:sub>\n                    source, its use in epoxide transfer hydrogenation holds significant challenges due to its high dehydrogenation energy and strong nucleophilicity, leading to methoxylation instead of hydrogenation. An unprecedented regiodivergent transfer hydrogenation of epoxides using methanol as the sustainable H\n                    <jats:sub>2<\/jats:sub>\n                    source, using a single Ir(III) catalyst, is reported here. The regioselectivity is controlled by strategic modulation of reaction conditions rather than catalyst variation. While KOTf and 2,2,2\u2010trifluoroethanol (TFE) helped in anti\u2010Markovnikov\u2010selective ring opening, KOH and\n                    <jats:sup>\n                      <jats:italic>t<\/jats:italic>\n                    <\/jats:sup>\n                    AmOH\u2010mediated conditions favored Markovnikov products. This methodology is further extended to a one\u2010pot\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010methylation of alcohols. Mechanistic investigations, including control and labeling experiments supported by density functional theory calculations, revealed the key factors governing regioselectivity. This work showcased the art of selective epoxide functionalization with regiodivergence through a strategic reaction condition modulation.\n                  <\/jats:p>","DOI":"10.1002\/cssc.202500687","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T08:54:52Z","timestamp":1749027292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Condition\u2010Modulated Regiodivergent Transfer Hydrogenation of Epoxide using Methanol as Sustainable H\n                    <sub>2<\/sub>\n                    Source"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3536-1741","authenticated-orcid":false,"given":"Ishani","family":"Borthakur","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Kanpur  Kanpur Uttar Pradesh 208016 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