{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T21:13:59Z","timestamp":1785359639604,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemSusChem"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:p>\n                    Diaryl ketones represent a pivotal class of compounds, widely used in pharmaceuticals, agrochemicals, and materials science. Driven by the urgent need for safer and more sustainable synthetic methodologies, developing innovative approaches in this area has become a critical priority for both academia and industry. In this context, a straightforward yet novel one\u2010pot strategy for synthesizing a broad array of diaryl ketones, including valuable target molecules, is presented. This approach diverges from conventional methods by employing a radical process, in which aryl halides react with benzonitriles in a basic medium, relying exclusively on the organic reductant pair KO\n                    <jats:sup>\n                      <jats:italic>t<\/jats:italic>\n                    <\/jats:sup>\n                    Bu\/DMA and air as the oxidant. Mechanistic studies suggest that the KO\n                    <jats:sup>\n                      <jats:italic>t<\/jats:italic>\n                    <\/jats:sup>\n                    Bu\/DMA system triggers the generation of aryl radicals, thereby initiating the process. This method stands out by overcoming key limitations of conventional approaches, notably avoiding corrosive reagents, toxic or expensive catalysts, peroxides, and hazardous carbon monoxide, thus aligning with the shift toward safer, more sustainable alternative synthetic strategies.\n                  <\/jats:p>","DOI":"10.1002\/cssc.202501478","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T11:30:04Z","timestamp":1758540604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Radical\u2010Based, Transition Metal\u2010Free Approach for Diaryl Ketone Synthesis"],"prefix":"10.1002","volume":"18","author":[{"given":"Dongjie","family":"Wang","sequence":"first","affiliation":[{"name":"D\u00e9partement Chimie &amp; Mat\u00e9riaux Mol\u00e9culaire Institut Charles Gerhardt de Montpellier CNRS ENSCM University of Montpellier  1919, route de Mende 34293 Montpellier Cedex 5 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Garo","sequence":"additional","affiliation":[{"name":"E2S UPPA CNRS IPREM Universit\u00e9 de Pau et des Pays de l\u2019Adour  Technop\u00f4le H\u00e9lioparc, 2 avenue du Pr\u00e9sident Pierre Angot  64053 Pau Cedex 9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinpeng","family":"Wang","sequence":"additional","affiliation":[{"name":"D\u00e9partement Chimie &amp; Mat\u00e9riaux Mol\u00e9culaire Institut Charles Gerhardt de Montpellier CNRS ENSCM University of Montpellier  1919, route de Mende 34293 Montpellier Cedex 5 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9513-3639","authenticated-orcid":false,"given":"Jean\u2010Marc","family":"Sotiropoulos","sequence":"additional","affiliation":[{"name":"E2S UPPA CNRS IPREM Universit\u00e9 de Pau et des Pays de l\u2019Adour  Technop\u00f4le H\u00e9lioparc, 2 avenue du Pr\u00e9sident Pierre Angot  64053 Pau Cedex 9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2991-5418","authenticated-orcid":false,"given":"Marc","family":"Taillefer","sequence":"additional","affiliation":[{"name":"D\u00e9partement Chimie &amp; Mat\u00e9riaux Mol\u00e9culaire Institut Charles Gerhardt de Montpellier CNRS ENSCM University of Montpellier  1919, route de Mende 34293 Montpellier Cedex 5 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/np070501z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4NP00027G"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1986.tb03459.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm050670l"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm900519b"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201402992"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.03.042"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8MD00300A"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557522666220602103104"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3RA02788K"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2023.123905"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano14040356"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.197203001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781420067934"},{"key":"e_1_2_8_16_1","volume-title":"Kirk\u2010Othmer Encyclopedia of Chemical Technology","author":"Olah G. 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Due to standard confidentiality periods the results presented in this article became eligible for disclosure only 18 months (publication date 27.03.2025) after the patent filing (international filing date 20.09.2024)."}],"container-title":["ChemSusChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cssc.202501478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T19:15:57Z","timestamp":1762283757000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cssc.202501478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,22]]},"references-count":55,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2025,11,4]]}},"alternative-id":["10.1002\/cssc.202501478"],"URL":"https:\/\/doi.org\/10.1002\/cssc.202501478","archive":["Portico"],"relation":{},"ISSN":["1864-5631","1864-564X"],"issn-type":[{"value":"1864-5631","type":"print"},{"value":"1864-564X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,22]]},"assertion":[{"value":"2025-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202501478"}}