{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T02:52:31Z","timestamp":1781232751579,"version":"3.54.1"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemSusChem"],"published-print":{"date-parts":[[2026,3,27]]},"abstract":"<jats:p>\n                    An efficient, electrochemical three\u2010component reaction for the synthesis of vinyl sulfonamides from cinnamic acids, SO\n                    <jats:sub>2<\/jats:sub>\n                    , and amines is reported. This metal\u2010free protocol utilizes inexpensive graphite electrodes and easy\u2010to\u2010use SO\n                    <jats:sub>2<\/jats:sub>\n                    stock solutions to facilitate a decarboxylative transformation under mild conditions. The reaction proceeds with high regio\u2010 and stereoselectivity. The use of cinnamic acid derivatives as biobased feedstocks, combined with the demonstrated scalability and electrode\/electrolyte reusability, highlights the potential of this approach for a sustainable synthesis of the important vinyl sulfonamide scaffold.\n                  <\/jats:p>","DOI":"10.1002\/cssc.202501920","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T05:20:59Z","timestamp":1766208059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Electrochemical Three\u2010Component Synthesis of Vinyl Sulfonamides via Decarboxylative Sulfonylation of Cinnamic Acids"],"prefix":"10.1002","volume":"19","author":[{"given":"Po\u2010Chung","family":"Chien","sequence":"first","affiliation":[{"name":"Department of Chemistry RPTU University Kaiserslautern\u2010Landau  Kaiserslautern Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Kelm","sequence":"additional","affiliation":[{"name":"Department of Chemistry RPTU University Kaiserslautern\u2010Landau  Kaiserslautern Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4013-5757","authenticated-orcid":false,"given":"Georg","family":"Manolikakes","sequence":"additional","affiliation":[{"name":"Department of Chemistry RPTU University Kaiserslautern\u2010Landau  Kaiserslautern Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"130","article-title":"The Evolving Role of Sulfonamides in Medicine and Drug Development: A Brief Review","volume":"7","author":"Bisharat H.","year":"2025","journal-title":"Advanced Journal of Chemistry, Section B: Natural Products and Medical Chemistry"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-1796646"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/polb.10281"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1108\/PRT-08-2015-0080"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(02)00021-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar700096h"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4OB02139H"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201705470"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol201957n"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1719864"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0036023610080310"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC03018C"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8MD00566D"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24451"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12796"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm400575x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114255"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e31817e9b9e"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm100146h"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.4c00378"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b02840"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202200112"},{"key":"e_1_2_9_24_1","first-page":"3639","article-title":"Sequential Reduction and Dehydration of phenacyl-(E)-styryl Sulfones to Unsymmetrical (E,E)-bis(styryl) Sulfones","volume":"20","author":"Mallireddigari M. R.","year":"2005","journal-title":"Synthesis"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202401065"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.202401899"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202001180"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC04027A"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2GC01909D"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/celc.202400360"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202400557"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.4c04746"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.5c00972"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5GC01138H"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2QO01821G"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202016164"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/celc.202300456"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC01428E"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1560444"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202208080"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.202500186"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2015.00116"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.202002141"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202204140"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00511"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00233"},{"key":"e_1_2_9_47_1","unstructured":"Configuration of the double bond could be assigned via the J coupling constants of the olefinic protons. Assignment using vicinal coupling constants was verified by single crystal X\u2010ray diffraction of product 7a (seeSupporting Information for more details). Deposition Numbers CCDC 2472612 contain the supplementary crystallographic data for this paper. These data are provided free of charge by the joint. Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe Access Structures servicehttps:\/\/www.ccdc.cam.ac.uk\/structures. Configurations of all other compounds were assigned by analogy based on H and C NMR spectroscopy)."},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1557\/mre.2020.42"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA10896A"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b01037"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b01353"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.6b00661"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.7b01741"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.26434\/chemrxiv\u20102025\u2010gsqzx"},{"key":"e_1_2_9_55_1","unstructured":"P.\u2010C.Chien H.Kelm andG.Manolikakes Chemotion Repository(2025) https:\/\/dx.doi.org\/10.14272\/collection\/PCC_2025\u201006\u201020."},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules191016058"},{"key":"e_1_2_9_57_1","article-title":"Preparation of 4,5-dihydroazole-4-carboxylic Acid Derivatives as Luminescent Substrates for Luciferase","author":"Maki S.","year":"2009","journal-title":"JP2009184932 A"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja02248a004"}],"container-title":["ChemSusChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cssc.202501920","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cssc.202501920","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cssc.202501920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:50:40Z","timestamp":1780563040000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cssc.202501920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,3,27]]}},"alternative-id":["10.1002\/cssc.202501920"],"URL":"https:\/\/doi.org\/10.1002\/cssc.202501920","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv-2025-gsqzx","asserted-by":"object"}]},"ISSN":["1864-5631","1864-564X"],"issn-type":[{"value":"1864-5631","type":"print"},{"value":"1864-564X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]},"assertion":[{"value":"2025-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202501920"}}