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Here, we introduce a 3D\u2010printed methodology that integrates high\u2010throughput screening of enzyme immobilisation with implementation in a continuous\u2010flow reactor using the same photopolymeric formulation. The surface of the printed objects was modified through imidazolium\u2010based supported ionic liquid phases. Immobilisation conditions for an enzymatic solution with alcohol dehydrogenase (ADH\u2010200) were rapidly evaluated in a 96\u2010well format using a colorimetric assay that enables quantitative comparison of activity and loading across multiples of conditions in a parallel fashion. Methyl\u2010imidazolium\u2010modified supports showed markedly higher enzymatic activity and immobilisation efficiency than other imidazolium\u2010based ionic liquids, and the best\u2010performing formulation was directly applied to functionalise the 3D\u2010printed honeycomb\u2010structured reactor. The resulting heterogeneous biocatalyst catalysed the oxidation of 1\u2010phenylethanol to acetophenone under continuous flow with high conversion at moderate residence times and sustained performance over several hundred hours on stream. This integrated 3D\u2010printed platform facilitates the identification of effective immobilisation chemistries and their translation to robust flow reactors, providing a general strategy for the rapid development of immobilised biocatalysts.<\/jats:p>","DOI":"10.1002\/cssc.70815","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:04:42Z","timestamp":1781777082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["3D\u2010Printed Platforms for Enzyme Immobilisation Screening and Direct Translation into Continuous\u2010Flow Biocatalysis"],"prefix":"10.1002","volume":"19","author":[{"given":"Simone","family":"Marchetti","sequence":"first","affiliation":[{"name":"Institute of Advanced Materials (INAM) Universitat Jaume I  Castell\u00f3n de la Plana 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