{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:19:25Z","timestamp":1787901565619,"version":"build-2784847793"},"reference-count":67,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["OPUS, 2019\/35\/B\/ST4\/02794"],"award-info":[{"award-number":["OPUS, 2019\/35\/B\/ST4\/02794"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemSusChem"],"published-print":{"date-parts":[[2026,8,27]]},"abstract":"<jats:p>\n                    The integration of sequential transformations requiring mutually incompatible conditions remains a fundamental challenge in synthetic chemistry. Here, we report a liquid\u2010assisted mechanochemical strategy that enables the one\u2010pot merging of base\u2010 and acid\u2010mediated processes within a single vessel, overcoming challenges associated with their integration under conventional solution\u2010phase conditions. This approach provides access to valuable\n                    <jats:italic>N<\/jats:italic>\n                    \u2010heterocyclic scaffolds while reducing solvent use and improving overall process efficiency. The sequence is initiated by the mechanochemical copper\u2010catalyzed Ullmann\u2013Goldberg C\uf8ffN coupling of unprotected \u03b2\u2010lactams with aryl iodides, which can be paused to afford\n                    <jats:italic>N<\/jats:italic>\n                    \u2010aryl \u03b2\u2010lactams in up to 98% yield. A strategically implemented liquid\u2010assisted grinding (LAG) step enables seamless integration of the C\uf8ffN coupling step with an acid\u2010mediated Fries\u2010type rearrangement of amides, providing access to 2,3\u2010dihydroquinolin\u20104\u2010ones in moderate to excellent yields under mechanochemical conditions. The protocol exhibits broad functional group tolerance, accommodates structurally complex substrates, and enables late\u2010stage functionalization. Gram\u2010scale mechanochemical synthesis of a key 2,3\u2010dihydroquinolin\u20104\u2010one intermediate, followed by its direct conversion to the WHO\u2010listed antimalarial drug chloroquine under solvent\u2010free milling conditions, highlights the scalability and practical utility of this approach.\n                  <\/jats:p>","DOI":"10.1002\/cssc.70938","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T12:02:51Z","timestamp":1786536171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanochemical Integration of Incompatible Reaction Environments for the One\u2010Pot Synthesis of Structurally Diverse\n                    <i>N<\/i>\n                    \u2010Heterocycles"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9897-808X","authenticated-orcid":false,"given":"Magdalena","family":"Dolna","sequence":"first","affiliation":[{"name":"Polish Academy of Sciences Institute of Organic Chemistry  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0108-933X","authenticated-orcid":false,"given":"Magdalena","family":"Cebula","sequence":"additional","affiliation":[{"name":"Polish Academy of Sciences Institute of Organic Chemistry  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5459-8026","authenticated-orcid":false,"given":"Bart\u0142omiej","family":"Furman","sequence":"additional","affiliation":[{"name":"Polish Academy of Sciences Institute of Organic Chemistry  Warsaw 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