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This transformation leverages curcumin, a naturally abundant and renewable polyphenol, as an efficient visible\u2010light photosensitizer and 2\u2010methyltetrahydrofuran (2\u2010MeTHF), a biomass\u2010derived solvent, establishing a sustainable catalytic system composed entirely of organic, bio\u2010derived components. The reaction proceeds efficiently at room temperature using molecular oxygen as the sole terminal oxidant, strictly avoiding transition metals, stoichiometric oxidants, and hazardous additives. A broad range of benzylic and aliphatic amines is converted to the corresponding imines in good to excellent yields (up to 98%), demonstrating the generality and practicality of the protocol. Comprehensive mechanistic investigations\u2014including light on\/off experiments, oxygen\u2010dependence studies, radical trapping, Stern\u2013Volmer fluorescence quenching studies and Hammett analysis\u2014support a sensitizer\u2010controlled aerobic photocatalytic pathway involving photoinduced electron transfer and oxygen\u2010mediated catalyst regeneration via superoxide radical anions. This work highlights the efficacy of natural pigments in driving high\u2010efficiency, sustainable organic transformations.<\/jats:p>","DOI":"10.1002\/cssc.70980","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T17:36:41Z","timestamp":1787074601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Curcumin\u2010Enabled Metal\u2010Free Photocatalytic Oxidation of Aryl\u2010 and Alkyl\u2010methanamines to Imines Under Green Conditions"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6421-6526","authenticated-orcid":false,"given":"Tommaso","family":"Castiglia","sequence":"first","affiliation":[{"name":"Dipartimento di Chimica Universit\u00e0 degli Studi di Bari Aldo Moro  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4656-0138","authenticated-orcid":false,"given":"Maria 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