{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:10:11Z","timestamp":1789186211752,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemSusChem"],"published-print":{"date-parts":[[2026,9,14]]},"abstract":"<jats:p>\n                    Nature relies on multifunctional microenvironments to combine substrate recognition, activation, and catalysis with remarkable efficiency. Inspired by this principle, we report heterogeneous synzymes generated by the supramolecular immobilization of pseudopeptidic zinc macrocyclic complexes onto UiO\u201067 for CO\n                    <jats:sub>2<\/jats:sub>\n                    activation and valorization. The zinc chiral pseudopeptidic macrocycles can be selectively prepared through solvent\u2010directed macrocyclization, exploiting the conformational preorganization of the precursors to create enzyme\u2010inspired catalytic motifs. Comprehensive structural and computational studies of hybrid materials reveal a defect\u2010driven encapsulation mechanism. The bulky macrocycles partially perturb the UiO\u201067 framework and reduce porosity, but also markedly improve the thermal stability of the hybrid materials. Despite this porosity loss, the hybrids display enhanced catalytic activity in the additive\u2010free cycloaddition of CO\n                    <jats:sub>2<\/jats:sub>\n                    to epoxides at ambient pressure. C3@UiO\u201067 outperforms both the pristine MOF and the molecular zinc complex, revealing a cooperative microenvironment where hydrogen\u2010bond\u2010stabilized \u201cnaked\u201d iodides promote epoxide ring opening and secondary amines assist CO\n                    <jats:sub>2<\/jats:sub>\n                    activation. Overall, this work shows that looking to nature for catalytic design principles can deliver bioinspired MOF\u2013macrocycle synzymes as robust platforms for mild and sustainable CO\n                    <jats:sub>2<\/jats:sub>\n                    coactivation and valorization.\n                  <\/jats:p>","DOI":"10.1002\/cssc.71010","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:40:26Z","timestamp":1787838026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioinspired Zinc Macrocycles Confined in UiO\u201067: A Heterogeneous Synzyme for Sustainable CO\n                    <sub>2<\/sub>\n                    Valorization"],"prefix":"10.1002","volume":"19","author":[{"given":"J. E.","family":"Chiva","sequence":"first","affiliation":[{"name":"Supramolecular and Sustainable Research Group Inorganic and Organic Department Universitat Jaume I  Castell\u00f3 de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"S\u00e1nchez\u2010Velandia","sequence":"additional","affiliation":[{"name":"Supramolecular and Sustainable Research Group Inorganic and Organic Department Universitat Jaume I  Castell\u00f3 de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Esteve","sequence":"additional","affiliation":[{"name":"Laboratoire de Chemie Supramol\u00e9culaire Institut de Science et d\u2019ing\u00e9nierie supramol\u00e9cularies (ISIS) Supramolecular and Sustainable Research Group Inorganic and Organic universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. G.","family":"Cirujano","sequence":"additional","affiliation":[{"name":"Supramolecular and Sustainable Research Group Inorganic and Organic Department Universitat Jaume I  Castell\u00f3 de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8288-0384","authenticated-orcid":false,"given":"C.","family":"Vicent","sequence":"additional","affiliation":[{"name":"SCIC Universitat Jaume I  Castell\u00f3 de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2483-6158","authenticated-orcid":false,"given":"N.","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Supramolecular and Sustainable Research Group Inorganic and Organic Department Universitat Jaume I  Castell\u00f3 de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8839-3819","authenticated-orcid":false,"given":"B.","family":"Altava","sequence":"additional","affiliation":[{"name":"Supramolecular and Sustainable Research Group Inorganic and Organic Department Universitat Jaume I  Castell\u00f3 de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6867-6240","authenticated-orcid":false,"given":"E.","family":"Garc\u00eda\u2010Verdugo","sequence":"additional","affiliation":[{"name":"Supramolecular and Sustainable Research Group Inorganic and Organic Department Universitat Jaume I  Castell\u00f3 de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfx214"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie2000192"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA10233C"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202404677"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11705-024-2477-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/catal12050563"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200805451"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gce.2025.05.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30020251"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b00606"},{"key":"e_1_2_8_12_1","first-page":"293","article-title":"Carbon Dioxide Transport by Proteic and Facilitated Transport Membranes","volume":"6","author":"Trachtenberg M. 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