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Among biomass\u2010derived molecules, furan serves as a key building block for constructing diverse, high\u2010value bioactive molecules. Herein, this study presents a highly chemoselective and regioselective Diels\u2013Alder (D\u2010A) reaction between biomass\u2010derived monosubstituted furans and acrylamides, followed by aromatization, enabling the efficient synthesis of the bioactive molecule\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N\u2010<\/jats:italic>\n                    Diethyl\u20103\u2010methylbenzamide (DEET) with excellent selectivity. Notably, the catalyst (Hf(OTf)\n                    <jats:sub>4<\/jats:sub>\n                    ) serves not only as the Lewis acid center but also as a conformation\u2010directing template and intermediate stabilizer in this reaction. Gram\u2010scale syntheses were performed in both tubular and continuous\u2010flow reactors, confirming the scalability of this process. This methodology offers broad applicability for the regioselective synthesis of multisubstituted aromatic products from biomass\u2010derived furans, providing a novel approach for the high\u2010value conversion of biomass into bioactive molecules.\n                  <\/jats:p>","DOI":"10.1002\/cssc.71089","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:55:21Z","timestamp":1791309321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tandem Diels\u2013Alder Cycloaddition\/Aromatization of Biomass\u2010Derived 2\u2010Methylfuran Toward Renewable\n                    <i>N,N\u2010<\/i>\n                    Diethyl\u20103\u2010Methylbenzamide"],"prefix":"10.1002","volume":"19","author":[{"given":"Hui\u2010Tong","family":"Hu","sequence":"first","affiliation":[{"name":"Anhui Province Key Laboratory of Biomass Chemistry CAS Key Laboratory of Urban Pollutant Conversion University 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