{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:51:29Z","timestamp":1791312689540,"version":"4.3.1"},"reference-count":63,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemSusChem"],"published-print":{"date-parts":[[2026,10,14]]},"abstract":"<jats:p>\n                    A photobiocatalytic strategy for the linear deracemization of \u03b2\u2010hydroxynitriles is presented. This method consists of a two\u2010step process, beginning with the oxidation of the corresponding alcohol racemate (250\u2009mM) using tetrabutylammonium decatungstate (TBADT, 2.5\u20135.0\u2009mol%) under 390\u2009nm light irradiation in acetonitrile. The second step involves an asymmetric biocatalytic reduction, carried out sequentially by addition of the required reagents with or without solvent evaporation depending on the selected alcohol dehydrogenase (ADH) enzyme and its tolerance to the organic solvent. Under the resulting aqueous conditions (25\u201375\u2009mM ketone intermediate), the enzymes exhibited high selectivity, enabling access to a series of optically active \u03b2\u2010hydroxynitriles, predominantly with excellent optical purities, leading to nine pairs of enantiomers in 88 to &gt;99%\n                    <jats:italic>ee<\/jats:italic>\n                    . The integration of two sustainable technologies, photo\u2010 and biocatalysis, provides a straightforward route to chiral \u03b2\u2010hydroxynitriles. In addition, sunlight\u2010driven applicability and scalability are demonstrated.\n                  <\/jats:p>","DOI":"10.1002\/cssc.71108","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:05:47Z","timestamp":1791309947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photobiocatalytic Linear Deracemization of \u03b2\u2010Hydroxynitriles"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6481-7750","authenticated-orcid":false,"given":"Sara","family":"Filgueira","sequence":"first","affiliation":[{"name":"Department of Organic and Inorganic Chemistry Instituto Universitario de Qu\u00edmica Organomet\u00e1lica Enrique Moles Universidad de Oviedo  Oviedo 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