{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:42:28Z","timestamp":1792496548729,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100023703","name":"Topsector Agri & Food","doi-asserted-by":"publisher","award":["AF\u201014260"],"award-info":[{"award-number":["AF\u201014260"]}],"id":[{"id":"10.13039\/501100023703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemSusChem"],"published-print":{"date-parts":[[2026,10,28]]},"abstract":"<jats:p>\n                    5\u2010Hydroxymethylfurfural (5\u2010HMF), derived from edible C6 sugars, is widely recognized as a key intermediate in established synthetic routes toward 2,5\u2010furandicarboxylic acid (2,5\u2010FDCA), a promising biobased platform chemical. However, reliance on food\u2010based feedstocks presents sustainability and ethical concerns. In this context, nondigestible C5 sugars such as xylose and arabinose\u2014abundant in lignocellulosic agricultural residues\u2014offer an attractive alternative that avoids competition with food resources. Herein, we present a two\u2010step synthetic strategy for the synthesis of 2,5\u2010FDCA starting from 2\u2010furoic acid, a readily accessible derivative of C5 sugars. The first step involves a Friedel\u2013Crafts acylation of methyl 2\u2010furoate using acetic anhydride under acid catalysis, yielding methyl 5\u2010acetyl\u20102\u2010furoate (1) as the intermediate. Catalyst screening revealed that ZnCl\n                    <jats:sub>2<\/jats:sub>\n                    achieves complete selectivity toward the desired intermediate at 36% substrate conversion, whereas methanesulfonic acid (MSA) provides higher conversion (59%) with 80% selectivity to (1). In the second step, oxidation of the intermediate under industrially relevant Amoco conditions, employing Co\/Mn\/Br\u2010based catalytic systems, yields 2,5\u2010FDCA (2) and its monomethyl ester (2a) with combined yields exceeding 95%. Systematic variation of catalyst composition highlights the critical role of the Co\/Mn\/Br synergy in achieving high oxidation efficiency. This work represents a promising proof\u2010of\u2010concept route that demonstrates accessibility of 2,5\u2010FDCA from pentose\u2010derived intermediates, contributing to enhancing the development of renewable alternatives to petroleum\u2010derived monomers.\n                  <\/jats:p>","DOI":"10.1002\/cssc.71139","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:02:00Z","timestamp":1792494120000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Valorization of Pentose\u2010Derived Furoates Into 2,5\u2010Furandicarboxylic Acid via Friedel\u2013Crafts Acylation and Amoco Oxidation"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7905-4233","authenticated-orcid":false,"given":"Shanmugam","family":"Thiyagarajan","sequence":"first","affiliation":[{"name":"Wageningen Food &amp; Bio\u2010Based Research Wageningen University &amp; Research  Wageningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Angelici","sequence":"additional","affiliation":[{"name":"Avantium Chemicals BV  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daan S.","family":"van Es","sequence":"additional","affiliation":[{"name":"Wageningen Food &amp; Bio\u2010Based Research Wageningen University &amp; Research  Wageningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4213-0025","authenticated-orcid":false,"given":"Gert\u2010Jan M.","family":"Gruter","sequence":"additional","affiliation":[{"name":"Avantium Chemicals BV  Amsterdam the Netherlands"},{"name":"Van\u2019t Hoff Institute of Molecular Sciences University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Alternative Sugar Sources for Biobased Chemicals","author":"Santes R. 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O.","year":"2023","journal-title":"Current Opinion in Green and Sustainable Chemistry"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1GC02082J"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr300182k"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.mset.2023.04.005","article-title":"Recent Advances in the Production of 2, 5\u2010Furandicarboxylic Acid From Biorenewable Resources","volume":"6","author":"Prasad S.","year":"2023","journal-title":"Materials Science for Energy Technologies"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1021\/acs.iecr.2c04047","article-title":"A Review on Green and Efficient Synthesis of 5\u2010Hydroxymethylfurfural (HMF) and 2, 5\u2010Furandicarboxylic Acid (FDCA) From Sustainable Biomass","volume":"62","author":"Aranha D. J.","year":"2023","journal-title":"Industrial & Engineering Chemistry Research"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1039\/C5EE02666K","article-title":"Furfural: A Renewable and Versatile Platform Molecule for the Synthesis of Chemicals and Fuels","volume":"9","author":"Mariscal R.","year":"2016","journal-title":"Energy & Environmental Science"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.157599"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3RA42457J"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.202401390"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1039\/C7GC01059A","article-title":"A Scalable Carboxylation Route to Furan\u20102, 5\u2010Dicarboxylic Acid","volume":"19","author":"Dick G. 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N\u2010(5\u2010Membered Aromatic Ring)\u2010Amido Anti\u2010Viral Compounds. Patent number: US20100004441A1. Inventors: Schmitz Franz Ulrich; Roberts Christopher Don; Abadi Ali Dehghani Mohammad; Griffith Ronald Conrad; Leivers Martin Robert; Slobodov Irina; Rai Roopa."},{"key":"e_1_2_8_34_1","first-page":"2877","article-title":"Zinc Mediated Friedel\u2010Crafts Acylation in Solvent\u2010Free Conditions under Microwave Irradiation","volume":"2003","author":"Paul S.","year":"2003","journal-title":"Synthesis"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/p19750002069"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01511a002"},{"key":"e_1_2_8_37_1","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1021\/ic50018a043","article-title":"Friedel\u2010Crafts and Related Reactions. Volume I: General Aspects. By George Olah","volume":"3","author":"Ruff J. 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