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Several antiviral therapies and vaccines have been developed to mitigate the spread of this infection. However, new approaches are required to battle emerging SARS\u2010CoV\u20102 variants containing mutations that can reduce the vaccines' efficacy. The use of a combination of antiviral drugs with inhibitors of mammalian target of rapamycin (mTOR) signalling pathways has emerged as one of the promising novel approach. In this study, we have shown that SF2523, a dual activity small molecule that inhibits PI3K and BRD4, acts synergistically with the antiviral drugs remdesivir (RDV) and MU\u2010UNMC\u20102. Our findings suggest that the mTOR pathways are necessary for SARS\u2010CoV\u20102 pathogenesis in human cells and that targeting PI3K\/BET (bromodomain and extra\u2010terminal domain proteins) alone or combined with antiviral therapies is beneficial in mitigating SARS\u2010CoV\u20102 and its variants of concern (VOCs).<\/jats:p>","DOI":"10.1002\/ctd2.66","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T11:01:49Z","timestamp":1651834909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Combining antiviral drugs with BET inhibitors is beneficial in combatting SARS\u2010CoV\u20102 infection"],"prefix":"10.1002","volume":"2","author":[{"given":"Arpan","family":"Acharya","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Experimental Neuroscience University of Nebraska Medical Center  Omaha Nebraska 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