{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:04:05Z","timestamp":1775275445439,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006673","name":"Fonds L\u00e9on Fredericq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006673","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin &amp;amp; Trans Imm"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pregnancy is an immune paradox. While the immune system is required for embryo implantation, placental development and progression of gestation, excessive inflammation is associated with pregnancy failure. Similarly, the cytokine <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A plays an important role in defence against extracellular pathogens, but its dysregulation can lead to pathogenic inflammation and tissue damage. Although expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 has been reported during pregnancy, the cellular source of this cytokine and its relevance to gestation are not clear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Here we define the kinetics and cellular source of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A in the uterus during healthy and abortion\u2010prone murine pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CBA<\/jats:styled-content>\/J x <jats:styled-content style=\"fixed-case\">DBA<\/jats:styled-content>\/2J abortion\u2010prone mating was used and compared to <jats:styled-content style=\"fixed-case\">CBA<\/jats:styled-content>\/J x <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c control mating.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We demonstrate that, irrespective of gestational health, the number of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017\u2010producing cells peaks during midterm pregnancy and is largely derived from the \u03b3\u03b4 T\u2010cell lineage. We identify \u03b3\u03b4 T, Th17, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8 T and <jats:styled-content style=\"fixed-case\">NKT<\/jats:styled-content> cells as the cellular source of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A in pregnant mice. Furthermore, we positively identify the V\u03b36<jats:sup>+<\/jats:sup> subset of uterine \u03b3\u03b4 T cells as the main producer of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A during both healthy pregnancy and abortive pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To conclude, the accumulation of uterine <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017<jats:sup>+<\/jats:sup> innate\u2010like T cells appears not to adversely impact the developing foetus. Collectively, our results show that <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017<jats:sup>+<\/jats:sup> \u03b3\u03b4 T cells are present in the uterus throughout the course of normal gestation and therefore may play an important role in healthy pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cti2.1008","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T19:07:33Z","timestamp":1517425653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Accumulation of IL\u201017<sup>+<\/sup> V\u03b36<sup>+<\/sup> \u03b3\u03b4 T cells in pregnant mice is not associated with spontaneous abortion"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4400-6477","authenticated-orcid":false,"given":"Barbara","family":"Polese","sequence":"first","affiliation":[{"name":"GIGA\u2010I<sup>3<\/sup> Center of Immunoendocrinology GIGA Research 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