{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:45:16Z","timestamp":1782301516615,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T00:00:00Z","timestamp":1549843200000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1068652"],"award-info":[{"award-number":["1068652"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin &amp; Trans Imm"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Meta\u2010analyses have now confirmed that persistent infections with cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>) can accelerate the onset of diseases of ageing, notably cardiovascular pathologies. We address the circumstances in which the association may be strong enough to warrant intervention to reduce the viral burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We compare markers of the burden of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> with established indices of vascular pathology in healthy adults (<jats:italic>n<\/jats:italic>\u00a0=\u00a082) and in renal transplant recipients (<jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a081). Levels of all inflammatory and vascular biomarkers and <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> antibodies were higher in <jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>, and flow\u2010mediated dilation (<jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>) values were lower indicating inferior endothelial function. In multivariable regression models without adjustment for estimated glomerular filtration rate (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> antibody levels, age and gender were independently associated with <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content>, whilst only <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> associated with <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> in healthy adults. After adjustment for <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>, associations between <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> antibody and <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content> were reduced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Carotid intima\u2010media thickness, FMD, eGFR and plasma levels of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> antibodies (reactive with a lysate, <jats:styled-content style=\"fixed-case\">CMV IE<\/jats:styled-content>\u20101 or <jats:styled-content style=\"fixed-case\">CMV gB<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">VCAM<\/jats:styled-content>\u20101, P\u2010selectin, <jats:styled-content style=\"fixed-case\">sIFN<\/jats:styled-content>\u03b1R2, <jats:styled-content style=\"fixed-case\">sTNFR<\/jats:styled-content>1, <jats:styled-content style=\"fixed-case\">sCD<\/jats:styled-content>14 and <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Levels of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> antibody predict declining endothelial health in <jats:styled-content style=\"fixed-case\">RTR<\/jats:styled-content> and not in healthy adults, presumably by reflecting a high burden of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>. The levels of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> antibodies were a poor reflection of plasma biomarkers thought to reflect \u2018inflammaging\u2019 or vascular damage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cti2.1043","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T11:53:42Z","timestamp":1549886022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A high burden of cytomegalovirus marks poor vascular health in transplant recipients more clearly than in the general population"],"prefix":"10.1002","volume":"8","author":[{"given":"Silvia","family":"Lee","sequence":"first","affiliation":[{"name":"School of Biomedical Science and the Curtin Health Innovation Research Institute Curtin University Bentley WA Australia"},{"name":"Department of Microbiology Pathwest Laboratory Medicine Perth WA 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