{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:43:02Z","timestamp":1790808182091,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T00:00:00Z","timestamp":1554508800000},"content-version":"vor","delay-in-days":95,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1068040"],"award-info":[{"award-number":["1068040"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin &amp; Trans Imm"],"published-print":{"date-parts":[[2019,1]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>Systemic sclerosis (SS<\/jats:styled-content>c) is an autoimmune disease characterised by fibrosis, vascular dysfunction and immune dysregulation. The pathogenesis of SS<\/jats:styled-content>c remains poorly understood, although studies have indicated a role for the innate immune response.<\/jats:p><\/jats:sec>Methods<\/jats:title>Here, we measured serum interleukin (IL<\/jats:styled-content>)\u20101\u03b1, IL<\/jats:styled-content>\u20101\u03b2 and IL<\/jats:styled-content>\u201018 levels in 105 SS<\/jats:styled-content>c patients and 47 healthy controls (HC<\/jats:styled-content>) and analysed them with respect to multiple clinical parameters.<\/jats:p><\/jats:sec>Results<\/jats:title>Serum IL<\/jats:styled-content>\u201018 concentrations were significantly higher in SS<\/jats:styled-content>c patients than in HC<\/jats:styled-content>, while no significant differences in concentrations of IL<\/jats:styled-content>\u20101\u03b1 and IL<\/jats:styled-content>\u20101\u03b2 were observed between SS<\/jats:styled-content>c and HC<\/jats:styled-content>. In both SS<\/jats:styled-content>c and HC<\/jats:styled-content> serum, IL<\/jats:styled-content>\u20101\u03b1 and IL<\/jats:styled-content>\u20101\u03b2 were positively correlated, while in SS<\/jats:styled-content>c, both cytokines negatively correlated with IL<\/jats:styled-content>\u201018. Serum IL<\/jats:styled-content>\u201018 was significantly negatively correlated with both carbon monoxide transfer coefficient (KCO<\/jats:styled-content>) and diffusing capacity of the lungs for carbon monoxide (DLCO<\/jats:styled-content>). Serum IL<\/jats:styled-content>\u20101\u03b2 was positively correlated with the modified Rodnan skin score (mRSS<\/jats:styled-content>), particularly in patients with limited subtype. DLCO<\/jats:styled-content>, KCO<\/jats:styled-content> and tricuspid regurgitation (TR<\/jats:styled-content>) velocity were significantly higher in patients with high serum IL<\/jats:styled-content>\u20101\u03b2. Serum IL<\/jats:styled-content>\u20101\u03b1 was significantly lower in SS<\/jats:styled-content>c patients with low KCO<\/jats:styled-content> and positively correlated with KCO<\/jats:styled-content>. SS<\/jats:styled-content>c patients with high serum IL<\/jats:styled-content>\u20101\u03b1 concentrations were more likely to have digital ulcers.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our data suggest that these IL<\/jats:styled-content>\u20101 family cytokines may have different roles in the pathogenesis of SS<\/jats:styled-content>c fibrotic complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cti2.1045","type":"journal-article","created":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T03:54:27Z","timestamp":1554609267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Analysis of serum interleukin(IL<\/scp>)\u20101\u03b1, IL<\/scp>\u20101\u03b2 and IL<\/scp>\u201018 in patients with systemic sclerosis"],"prefix":"10.1002","volume":"8","author":[{"given":"Emily","family":"Lin","sequence":"first","affiliation":[{"name":"Rheumatology Group Centre for Inflammatory Diseases School of Clinical Sciences at Monash Health Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7220-0800","authenticated-orcid":false,"given":"Fabien B","family":"Vincent","sequence":"additional","affiliation":[{"name":"Rheumatology Group Centre for Inflammatory Diseases School of Clinical Sciences at Monash Health Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Sahhar","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Monash Health & Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene\u2010Siew","family":"Ngian","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Monash Health & Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rangi","family":"Kandane\u2010Rathnayake","sequence":"additional","affiliation":[{"name":"Rheumatology Group Centre for Inflammatory Diseases School of Clinical Sciences at Monash Health Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Mende","sequence":"additional","affiliation":[{"name":"Rheumatology Group Centre for Inflammatory Diseases School of Clinical Sciences at Monash Health Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric F","family":"Morand","sequence":"additional","affiliation":[{"name":"Rheumatology Group Centre for Inflammatory Diseases School of Clinical Sciences at Monash Health Monash University Clayton VIC Australia"},{"name":"Department of Rheumatology Monash Health & Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tali","family":"Lang","sequence":"additional","affiliation":[{"name":"Rheumatology Group Centre for Inflammatory Diseases School of Clinical Sciences at Monash Health Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5634-9637","authenticated-orcid":false,"given":"James","family":"Harris","sequence":"additional","affiliation":[{"name":"Rheumatology Group Centre for Inflammatory Diseases School of Clinical Sciences at Monash Health Monash University Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130312"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32834b0dac"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02642.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6064830"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22179"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9848-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2001.00321.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.2.447S"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2691"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.4049\/jimmunol.163.7.3969","article-title":"Intracellular IL\u20101 receptor antagonist is elevated in human dermal fibroblasts that overexpress intracellular precursor IL\u20101 alpha","volume":"163","author":"Higgins GC","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_8_13_1","first-page":"1946","article-title":"Autocrine activation by interleukin 1alpha induces the fibrogenic phenotype of systemic sclerosis fibroblasts","volume":"31","author":"Kawaguchi Y","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330619"},{"key":"e_1_2_8_15_1","first-page":"81","article-title":"Interleukin 1alpha single\u2010nucleotide polymorphism associated with systemic sclerosis","volume":"31","author":"Hutyrova B","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23451"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12011"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30568"},{"key":"e_1_2_8_19_1","first-page":"3786","article-title":"IL\u20101R1\/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice","volume":"117","author":"Gasse P","year":"2007","journal-title":"J Clin Invest"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(92)90158-K"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.019224"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.08.003"},{"key":"e_1_2_8_23_1","first-page":"5","article-title":"Expression of NLRP3 inflammasome, cytokines and vascular mediators in the skin of systemic sclerosis patients","volume":"17","author":"Martinez\u2010Godinez MA","year":"2015","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.224"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.302"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-016-0202-3"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.15171\/jnp.2016.05"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01250"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005037"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.128.5.2177"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203301"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181692"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350111"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.23758.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1147-2"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/37.12.1287"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1042"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-014-0480-6"},{"key":"e_1_2_8_40_1","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"LeRoy EC","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.5301\/jsrd.5000231"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.06.009"}],"container-title":["Clinical & Translational Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cti2.1045","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cti2.1045","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cti2.1045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T16:37:58Z","timestamp":1694363878000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cti2.1045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/cti2.1045"],"URL":"https:\/\/doi.org\/10.1002\/cti2.1045","archive":["Portico"],"relation":{},"ISSN":["2050-0068","2050-0068"],"issn-type":[{"value":"2050-0068","type":"print"},{"value":"2050-0068","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"2018-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1045"}}