{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:26:40Z","timestamp":1781893600922,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"vor","delay-in-days":308,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin &amp;amp; Trans Imm"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Effects of Zika virus (ZIKV) infection on placental development during pregnancy are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Full\u2010term placentas from three women, each infected with <jats:styled-content style=\"fixed-case\">ZIKV<\/jats:styled-content> during specific pregnancy trimesters, were harvested for anatomic, immunologic and transcriptomic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study, each woman exhibited a unique immune response with raised <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IP<\/jats:styled-content>\u201010, <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RANTES<\/jats:styled-content> expression and neutrophil numbers during the acute infection phase. Although <jats:styled-content style=\"fixed-case\">ZIKV NS<\/jats:styled-content>3 antigens co\u2010localised to placental Hofbauer cells, the placentas showed no anatomic defects. Transcriptomic analysis of samples from the placentas revealed that infection during trimester 1 caused a disparate cellular response centred on differential <jats:styled-content style=\"fixed-case\">eIF<\/jats:styled-content>2 signalling, mitochondrial dysfunction and oxidative phosphorylation. Despite these, the babies were delivered without any congenital anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings should translate to improve clinical prenatal screening procedures for virus\u2010infected pregnant patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cti2.1082","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T06:06:24Z","timestamp":1573020384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Immunological observations and transcriptomic analysis of trimester\u2010specific full\u2010term placentas from three Zika virus\u2010infected women"],"prefix":"10.1002","volume":"8","author":[{"given":"Fok\u2010Moon","family":"Lum","sequence":"first","affiliation":[{"name":"Singapore Immunology Network Agency for Science, Technology and Research Singapore 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