{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T11:43:53Z","timestamp":1768650233921,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":249,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013143","name":"National Natural Science Foundation of China-Shandong Joint Fund for Marine Science Research Centers","doi-asserted-by":"publisher","award":["81472111"],"award-info":[{"award-number":["81472111"]}],"id":[{"id":"10.13039\/501100013143","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin &amp; Trans Imm"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Bone destruction is a remarkable feature of inflammatory arthritis. It remains unknown why arthritis associated with the systemic autoimmune\/inflammatory condition systemic lupus erythematosus (SLE) does not result in erosion and destruction. We aimed to determine the role of autoantibody in the pathogenesis of non\u2010erosive arthritis in SLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed medical record of SLE patients, investigated whether autoantibody induces arthritis lacking bone destruction in animal models and determined whether SLE autoantibody inhibits osteoclastogenesis induced by RANKL<jats:italic>in vitro<\/jats:italic>experiments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that arthritis lacking bone erosions is common in SLE patients and lupus\u2010prone mice. Intraarticular injection of lupus serum or IgG induces immune complex deposition and arthritis, but does not result in bone destruction. Deposition of IgG, monocytes\/macrophages and TNF\u2010\u03b1 is all required for the development of arthritis. Lupus serum or IgG inhibits RANKL\u2010induced differentiation of monocytes into osteoclast in a dose\u2010dependent manner. Fc\u03b3R acts as co\u2010receptors for RANKL and is involved in osteoclastogenesis. Deficiency of Fc\u03b3RII or Fc\u03b3RIII does not affect osteoclastogenesis in the presence of SLE IgG. However, lupus IgG competes for Fc\u03b3RI binding with RANKL, thereby reducing osteoclastogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Observations from this study demonstrate that IgG from SLE patients can induce arthritis and inhibits RANKL\u2010induced osteoclastogenesis through competitive occupation of Fc\u03b3RI on monocytes\/macrophages. This study improves the understanding of the pathophysiology of SLE\u2010associated arthritis and offers a protective mechanism (Fc\u03b3RI inhibition) that may be targeted in other forms of autoimmune\/inflammatory arthritis, such as RA, to prevent or limit bone erosion and inflammatory bone loss.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cti2.1174","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T06:25:47Z","timestamp":1601187947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lupus IgG deposition causes arthritis but inhibits bone destruction through competitive occupation of Fc\u03b3RI and reduced RANKL signalling"],"prefix":"10.1002","volume":"9","author":[{"given":"Wei","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory The fourth affiliated hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Orthopedics BenQ Medical Center The affiliated BenQ Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyue","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Likai","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"M Hedrich","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s &amp; 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