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Evidence for this hypothesis includes the fact that antibodies as well as T\u2010cell responses to heat\u2010shock proteins (HSPs) are detectable in some patients with glaucoma and in an animal model of the disease. As in the human disease, experimental animal models of glaucoma have been found to demonstrate neurodegenerative changes in the optic nerve associated with immunoglobulin and T\u2010cell infiltration. 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