{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T11:55:21Z","timestamp":1774698921742,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":296,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671117"],"award-info":[{"award-number":["81671117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30870125"],"award-info":[{"award-number":["30870125"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["SBK201402229"],"award-info":[{"award-number":["SBK201402229"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin &amp; Trans Imm"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Osteoarthritis (OA) is the most common form of arthritis characterised by cartilage degradation, synovitis and pain. Disease modifying treatments for OA are not available. The critical unmet need is to find therapeutic targets to reduce both disease progression and pain. The cytokine IL\u201033 and its receptor ST2 have been shown to play a role in immune and inflammatory diseases, but their role in osteoarthritis is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Non\u2010OA and OA human chondrocytes samples were examined for IL\u201033 and ST2 expression. Novel inducible cartilage specific knockout mice (IL\u201033\n                      <jats:sup>Acan CreERT2<\/jats:sup>\n                      ) and inducible fibroblast\u2010like synoviocyte knockout mice (IL\u201033\n                      <jats:sup>Col1a2 CreERT2<\/jats:sup>\n                      ) were generated and subjected to an experimental OA model. In addition, wild\u2010type mice were intra\u2010articularly administered with either IL\u201033\u2010 or ST2\u2010neutralising antibodies during experimental OA studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IL\u201033 and its receptor ST2 have increased expression in OA patients and a murine disease model. Administering recombinant IL\u201033 increased OA and pain\n                      <jats:italic>in vivo<\/jats:italic>\n                      . Synovial fibroblast\u2010specific deletion of IL\u201033 decreased synovitis but did not impact disease outcomes, whilst cartilage\u2010specific deletion of IL\u201033 improved disease outcomes\n                      <jats:italic>in vivo<\/jats:italic>\n                      . Blocking IL\u201033 signalling also reduced the release of cartilage\u2010degrading enzymes in human and mouse chondrocytes. Most importantly, we show the use of monoclonal antibodies against IL\u201033 and ST2 attenuates both OA and pain\n                      <jats:italic>in vivo<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, our data reveal blockade of IL\u201033 signalling as a viable therapeutic target for OA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cti2.1187","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T21:28:40Z","timestamp":1603488520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Blockade of IL\u201033 signalling attenuates osteoarthritis"],"prefix":"10.1002","volume":"9","author":[{"given":"Zengliang","family":"He","sequence":"first","affiliation":[{"name":"Department of Orthopedics The Second Hospital of Nanjing The Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Second Hospital of Nanjing The Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongxiang","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Second Hospital of Nanjing The Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengzhuo","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Neurology The Sir Run Run Hospital Nanjing Medical University Nanjing 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