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However, dysregulation in the immune system elicits excess\/abnormal inflammation resulting in unintended tissue damage and causes major inflammatory diseases including asthma, chronic obstructive pulmonary disease, atherosclerosis, inflammatory bowel diseases, sarcoidosis and rheumatoid arthritis. It is now widely accepted that both endoplasmic reticulum (ER) stress and inflammasomes play critical roles in activating inflammatory signalling cascades. Notably, evidence is mounting for the involvement of ER stress in exacerbating inflammasome\u2010induced inflammatory cascades, which may provide a new axis for therapeutic targeting in a range of inflammatory disorders. Here, we comprehensively review the roles, mechanisms and interactions of both ER stress and inflammasomes, as well as their interconnected relationships in inflammatory signalling cascades. We also discuss novel therapeutic strategies that are being developed to treat ER stress\u2010 and inflammasome\u2010related inflammatory disorders.<\/jats:p>","DOI":"10.1002\/cti2.1247","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T04:29:58Z","timestamp":1613276998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders"],"prefix":"10.1002","volume":"10","author":[{"given":"Wai Chin","family":"Chong","sequence":"first","affiliation":[{"name":"Department of Molecular and Translational Science Monash University Clayton VIC Australia"},{"name":"Centre for Cancer Research Hudson Institute of Medical Research Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhur 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