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A small proportion of children exposed to severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) or infected by\n                    <jats:italic>Yersinia<\/jats:italic>\n                    reproducibly develop principal symptoms of KD in various ethnic areas, but not in all studies. These microbes provoke a rapid cell\u2010damaging process, called \u2018pyroptosis\u2019, which is characterised by a subsequent release of proinflammatory cellular components from damaged endothelial and innate immune cells. In agreement with these molecular events, patients with KD show elevated levels of damage\u2010associated molecular patterns derived from cell death. In addition, an overwhelming amount of oxidative stress\u2010associated molecules, including oxidised phospholipids or low\u2010density lipoproteins, are generated as by\u2010products of inflammation during the acute phase of the disease. These molecules induce abnormalities in the acquired immune system and activate innate immune and vascular cells to produce a range of proinflammatory molecules such as cytokines, chemokines, proteases and reactive oxygen species. These responses further recruit immune cells to the arterial wall, wherein inflammation and oxidative stress closely interact and mutually amplify each other. The inflammasome, a key component of the innate immune system, plays an essential role in the development of vasculitis in KD. Thus, innate immune memory, or \u2018trained immunity\u2019, may promote vasculitis in KD. Hence, this review will be helpful in understanding the pathophysiologic pathways leading to the development of principal KD symptoms and coronary artery lesions in patients with KD, as well as in subsets of patients with SARS\u2010CoV\u20102 and\n                    <jats:italic>Yersinia<\/jats:italic>\n                    infections.\n                  <\/jats:p>","DOI":"10.1002\/cti2.1284","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T15:27:58Z","timestamp":1620660478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["The up\u2010to\u2010date pathophysiology of Kawasaki disease"],"prefix":"10.1002","volume":"10","author":[{"given":"Toshiro","family":"Hara","sequence":"first","affiliation":[{"name":"Kawasaki Disease Center Fukuoka Children\u2019s Hospital Fukuoka 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