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The presence of coincident inflammation in the lungs and eyes of neonates receiving oxygen therapy indicates that a dysregulated immune response serves as a potential common pathogenic factor for both diseases. This review examines the current state of knowledge of immunological dysregulation in BPD and ROP, identifying similarities in the cellular subsets and inflammatory cytokines that are found in the alveoli and retina during the active phase of these diseases, indicating possible mechanistic overlap. In addition, we highlight gaps in the understanding of whether these responses emerge independently in the lung and retina as a consequence of oxygen exposure or arise because of inflammatory spill\u2010over from the lung. As BPD and ROP are anatomically distinct, they are often considered discreet disease entities and are therefore treated separately. We propose that an improved understanding of the relationship between BPD and ROP is key to the identification of novel therapeutic targets to treat or prevent both conditions simultaneously.<\/jats:p>","DOI":"10.1002\/cti2.1322","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T03:11:10Z","timestamp":1629947470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The immunological link between neonatal lung and eye disease"],"prefix":"10.1002","volume":"10","author":[{"given":"Lakshanie C","family":"Wickramasinghe","sequence":"first","affiliation":[{"name":"Leukocyte Signalling Laboratory Department of Immunology and Pathology Central Clinical School Monash University Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"van Wijngaarden","sequence":"additional","affiliation":[{"name":"Ophthalmology Department of Surgery 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