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Here, we comprehensively evaluated the reconstitution of T\u2010 and B\u2010cell compartments in 29 SCD patients treated with allo\u2010HSCT and how it correlated with the development of acute graft\u2010versus\u2010host disease (aGvHD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>T\u2010cell neogenesis was assessed by quantification of signal\u2010joint and \u03b2\u2010chain TCR excision circles. B\u2010cell neogenesis was evaluated by quantification of signal\u2010joint and coding\u2010joint K\u2010chain recombination excision circles. T\u2010 and B\u2010cell peripheral subset numbers were assessed by flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before allo\u2010HSCT (baseline), T\u2010cell neogenesis was normal in SCD patients compared with age\u2010, gender\u2010 and ethnicity\u2010matched healthy controls. Following allo\u2010HSCT, T\u2010cell neogenesis declined but was fully restored to healthy control levels at one year post\u2010transplantation. Peripheral T\u2010cell subset counts were fully restored only at 24 months post\u2010transplantation. Occurrence of acute graft\u2010versus\u2010host disease (aGvHD) transiently affected T\u2010 and B\u2010cell neogenesis and overall reconstitution of T\u2010 and B\u2010cell peripheral subsets. B\u2010cell neogenesis was significantly higher in SCD patients at baseline than in healthy controls, remaining high throughout the follow\u2010up after allo\u2010HSCT. Notably, after transplantation SCD patients showed increased frequencies of IL\u201010\u2010producing B\u2010regulatory cells and IgM<jats:sup>+<\/jats:sup>memory B\u2010cell subsets compared with baseline levels and with healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings revealed that the T\u2010 and B\u2010cell compartments were normally reconstituted in SCD patients after allo\u2010HSCT. In addition, the increase of IL\u201010\u2010producing B\u2010regulatory cells may contribute to improve immune regulation and homeostasis after transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cti2.1389","type":"journal-article","created":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T03:39:36Z","timestamp":1650771576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Allogeneic haematopoietic stem cell transplantation resets T\u2010 and B\u2010cell compartments in sickle cell disease patients"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6188-4861","authenticated-orcid":false,"given":"Luciana Ribeiro","family":"Jarduli\u2010Maciel","sequence":"first","affiliation":[{"name":"Graduate Program in Biosciences Applied to Pharmacy School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto SP Brazil"},{"name":"Center for 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