{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:32:28Z","timestamp":1791923548354,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["70114663"],"award-info":[{"award-number":["70114663"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin &amp; Trans Imm"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Infection with severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) causes coronavirus disease 2019 (COVID\u201019). Although an acute SARS\u2010CoV\u20102 infection mainly presents with respiratory illness, neurologic symptoms and sequelae are increasingly recognised in the long\u2010term treatment of COVID\u201019 patients. The pathophysiology and the neuropathogenesis behind neurologic complications of COVID\u201019 remain poorly understood, but mounting evidence points to endothelial dysfunction either directly caused by viral infection or indirectly by inflammatory cytokines, followed by a local immune response that may include virus\u2010specific T\u00a0cells. However, the type and role of central nervous system\u2010infiltrating T cells in COVID\u201019 are complex and not fully understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed distinct anatomical brain regions of patients who had deceased as a result of COVID\u201019\u2010associated pneumonia or complications thereof and performed T cell receptor V\u03b2 repertoire sequencing. Clonotypes were analysed for SARS\u2010CoV\u20102 association using public TCR repertoire data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our descriptive study demonstrates that SARS\u2010CoV\u20102\u2010associated T cells are found in almost all brain areas of patients with fatal COVID\u201019 courses. The olfactory bulb, medulla and cerebellum were brain regions showing the most SARS\u2010CoV\u20102 specific sequence patterns. Neuropathological workup demonstrated primary CD8<jats:sup>+<\/jats:sup> T\u2010cell infiltration with a perivascular infiltration pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Future research is needed to better define the relationship between T\u2010cell infiltration and neurological symptoms and its long\u2010term impact on patients' cognitive and mental health.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cti2.1487","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T05:15:35Z","timestamp":1706764535000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["SARS\u2010CoV\u20102\u2010associated T\u2010cell infiltration in the central nervous system"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0627-9092","authenticated-orcid":false,"given":"Malte","family":"Mohme","sequence":"first","affiliation":[{"name":"Department of Neurosurgery University Medical Centre Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schulthei\u00df","sequence":"additional","affiliation":[{"name":"Medical Oncology University Hospital Basel  Basel Switzerland"},{"name":"Laboratory of Translational Immuno\u2010Oncology, Department of Biomedicine University of Basel and University Hospital of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Piffko","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Medical Centre Hamburg\u2010Eppendorf  Hamburg 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