{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:27:43Z","timestamp":1789104463112,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["91719305"],"award-info":[{"award-number":["91719305"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016032","name":"Nederlandse Cystic Fibrosis Stichting","doi-asserted-by":"publisher","award":["HIT\u2010CF"],"award-info":[{"award-number":["HIT\u2010CF"]}],"id":[{"id":"10.13039\/100016032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL126603"],"award-info":[{"award-number":["R01HL126603"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["TIROU19A0"],"award-info":[{"award-number":["TIROU19A0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin &amp;amp; Trans Imm"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In cystic fibrosis (CF), an imbalanced lipid metabolism is associated with lung inflammation. Little is known about the role that specific lipid mediators (LMs) exert in CF lung inflammation, and whether their levels change during early disease progression. Therefore, we measured airway LM profiles of young CF patients, correlating these with disease\u2010associated parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Levels of omega (\u03c9)\u20103\/6 PUFAs and their LM derivatives were determined in bronchoalveolar lavage fluid (BALF) of children with CF ages 1\u20135 using a targeted high\u2010performance liquid chromatography\u2013tandem mass spectrometry approach. Hierarchical clustering analysis was performed on relative LM levels. Individual relative LM levels were correlated with neutrophilic inflammation (BALF %Neu) and structural lung damage (PRAGMA\u2010CF %Disease). Significant correlations were included in a backward multivariate linear regression model to identify the LMs that are best related to disease progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 65 BALF samples were analysed for \u03c9\u20103\/6 lipid content. LM profiles clustered into an arachidonic acid (AA)\u2010enriched and a linoleic acid (LA)\u2010enriched sample cluster. AA derivatives like 17\u2010OH\u2010DH\u2010HETE, 5\u2010HETE, 5,15\u2010diHETE, 15\u2010HETE, 15\u2010KETE, LTB<jats:sub>4<\/jats:sub> and 6\u2010trans\u2010LTB<jats:sub>4<\/jats:sub> positively correlated with BALF %Neu and\/or PRAGMA %Dis. Contrastingly, 9\u2010HoTrE and the LA derivatives 9\u2010HoDE, 9(10)\u2010EpOME, 9(10)\u2010DiHOME, 13\u2010HoDE, 13\u2010oxoODE and 12(13)\u2010EpOME negatively correlated with BALF %Neu and\/or PRAGMA %Dis. 6\u2010trans\u2010LTB<jats:sub>4<\/jats:sub> was the strongest predictor for BALF %Neu. 5\u2010HETE and 15\u2010KETE contributed most to PRAGMA %Dis prediction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data provide more insight into the lung lipidome of infants with CF, and show that a shift from LA derivatives to AA derivatives in BALF associates with early CF lung disease progression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cti2.70000","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T11:03:57Z","timestamp":1726484637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Omega\u20106 Lipid pathway shift is associated with neutrophil influx and structural lung damage in early cystic\u00a0fibrosis lung disease"],"prefix":"10.1002","volume":"13","author":[{"given":"Lisa JM","family":"Slimmen","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine and Allergology, Department of Paediatrics Erasmus MC Sophia Children's Hospital, Erasmus University Medical Centre  Rotterdam The Netherlands"},{"name":"Laboratory of Paediatrics, Infection and Immunity Group, Department of Paediatrics Erasmus University Medical Centre  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelle Y","family":"Broos","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology and Immunology, MS Centre Amsterdam Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC  Amsterdam The Netherlands"},{"name":"Center for Proteomics and Metabolomics Leiden University Medical Centre  Leiden The 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