{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:14:00Z","timestamp":1790828040067,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":323,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin &amp;amp; Trans Imm"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Dysregulation of Epstein\u2013Barr virus (EBV)\u2010specific cellular immunity has been hypothesised as one of the contributing factors in the pathogenesis of systemic lupus erythematosus (SLE). Lupus nephritis is a major risk factor for overall morbidity in SLE. Immune\u2010based strategies directed to EBV have been proposed as potential therapeutic strategy for SLE and lupus nephritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Autologous EBV latent antigen\u2010specific CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T\u00a0cells were expanded <jats:italic>in vitro<\/jats:italic> and adoptively transferred to a lupus nephritis patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This adoptive immunotherapy had no immediate adverse effects, and the patient was subsequently treated with the anti\u2010CD20 antibody, obinutuzumab. The patient showed a reduction in anti\u2010dsDNA antibodies and improved glomerular filtration rate but remained nephrotic. These observations were coincident with a reduction in anti\u2010viral and global T\u2010cell activation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To our knowledge, this is the first report of the use of EBV\u2010specific adoptive immunotherapy to treat a patient with lupus nephritis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cti2.70015","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T10:50:27Z","timestamp":1732013427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Autologous Epstein\u2013Barr virus\u2010specific adoptive T\u2010cell therapy in a patient with lupus nephritis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1215-1773","authenticated-orcid":false,"given":"Dwarakanathan","family":"Ranganathan","sequence":"first","affiliation":[{"name":"Kidney Health Service Royal Brisbane and Women's 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